Cardiovascular responses elicited by hypothalamic stimulation in rabbits reveal a mediolateral organization

Marc Gellman, Neil Schneiderman, Jeffrey H. Wallach, William LeBlanc

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Heart rate and blood pressure response patterns were elicited by relatively low intensity (∼0.2 mA) stimulation (10 s trains; 100 pulses/s; 0.25 ms pulse duration) in different regions of the hypothalamus in anesthetized rabbits. A bradycardia/depressor pattern was elicited from both anterior and posterior stimulating electrode sites in the far lateral hypothalamus. Medial sites including the ventromedial hypothalamus elicited a tachycardia/pressor pattern. A bradycardia/pressor pattern was elicited from both the anterior and posterior hypothalamus at sites between the lateral hypothalamic (bradycardia/depressor) and the medial hypothalamic (tachycardia/pressor) zones. Paralysis by injection of decamethonium in conjunction with artificial ventilation did not reveal systematic differences in cardiovascular response threshold, form, or magnitude between the paralyzed and non-paralyzed state, indicating that the cardiovascular response patterns were not secondary to changes in respiration. Bilateral vagotomy abolished the bradycardia responses evoked by hypothalamic stimulation indicating that the cardiodeceleration was mediated by the vagus nerves; vagotomy attenuated tachycardia responses indicating that the responses in part reflected a decrease in vagal restraint. Bradycardia responses to ipsilateral but not contralateral hypothalamic stimulation were attenuated or abolished when examined.

Original languageEnglish
Pages (from-to)301-317
Number of pages17
JournalJournal of the Autonomic Nervous System
Volume4
Issue number4
DOIs
StatePublished - Jan 1 1981

Fingerprint

Bradycardia
Rabbits
Tachycardia
Vagotomy
Hypothalamus
Lateral Hypothalamic Area
Posterior Hypothalamus
Anterior Hypothalamus
Vagus Nerve
Paralysis
Electrodes
Respiration
Heart Rate
Blood Pressure
Injections

Keywords

  • amygdala central nucleus
  • blood pressure
  • heart rate
  • hypothalamus
  • intracranial stimulation
  • rabbits

ASJC Scopus subject areas

  • Physiology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Cardiovascular responses elicited by hypothalamic stimulation in rabbits reveal a mediolateral organization. / Gellman, Marc; Schneiderman, Neil; Wallach, Jeffrey H.; LeBlanc, William.

In: Journal of the Autonomic Nervous System, Vol. 4, No. 4, 01.01.1981, p. 301-317.

Research output: Contribution to journalArticle

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