Abstract
Heart rate and blood pressure response patterns were elicited by relatively low intensity (∼0.2 mA) stimulation (10 s trains; 100 pulses/s; 0.25 ms pulse duration) in different regions of the hypothalamus in anesthetized rabbits. A bradycardia/depressor pattern was elicited from both anterior and posterior stimulating electrode sites in the far lateral hypothalamus. Medial sites including the ventromedial hypothalamus elicited a tachycardia/pressor pattern. A bradycardia/pressor pattern was elicited from both the anterior and posterior hypothalamus at sites between the lateral hypothalamic (bradycardia/depressor) and the medial hypothalamic (tachycardia/pressor) zones. Paralysis by injection of decamethonium in conjunction with artificial ventilation did not reveal systematic differences in cardiovascular response threshold, form, or magnitude between the paralyzed and non-paralyzed state, indicating that the cardiovascular response patterns were not secondary to changes in respiration. Bilateral vagotomy abolished the bradycardia responses evoked by hypothalamic stimulation indicating that the cardiodeceleration was mediated by the vagus nerves; vagotomy attenuated tachycardia responses indicating that the responses in part reflected a decrease in vagal restraint. Bradycardia responses to ipsilateral but not contralateral hypothalamic stimulation were attenuated or abolished when examined.
| Original language | English |
|---|---|
| Pages (from-to) | 301-317 |
| Number of pages | 17 |
| Journal | Journal of the Autonomic Nervous System |
| Volume | 4 |
| Issue number | 4 |
| DOIs | |
| State | Published - Jan 1 1981 |
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Keywords
- amygdala central nucleus
- blood pressure
- heart rate
- hypothalamus
- intracranial stimulation
- rabbits
ASJC Scopus subject areas
- Physiology
- Clinical Neurology
- Neuroscience(all)
Cite this
Cardiovascular responses elicited by hypothalamic stimulation in rabbits reveal a mediolateral organization. / Gellman, Marc; Schneiderman, Neil; Wallach, Jeffrey H.; LeBlanc, William.
In: Journal of the Autonomic Nervous System, Vol. 4, No. 4, 01.01.1981, p. 301-317.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cardiovascular responses elicited by hypothalamic stimulation in rabbits reveal a mediolateral organization
AU - Gellman, Marc
AU - Schneiderman, Neil
AU - Wallach, Jeffrey H.
AU - LeBlanc, William
PY - 1981/1/1
Y1 - 1981/1/1
N2 - Heart rate and blood pressure response patterns were elicited by relatively low intensity (∼0.2 mA) stimulation (10 s trains; 100 pulses/s; 0.25 ms pulse duration) in different regions of the hypothalamus in anesthetized rabbits. A bradycardia/depressor pattern was elicited from both anterior and posterior stimulating electrode sites in the far lateral hypothalamus. Medial sites including the ventromedial hypothalamus elicited a tachycardia/pressor pattern. A bradycardia/pressor pattern was elicited from both the anterior and posterior hypothalamus at sites between the lateral hypothalamic (bradycardia/depressor) and the medial hypothalamic (tachycardia/pressor) zones. Paralysis by injection of decamethonium in conjunction with artificial ventilation did not reveal systematic differences in cardiovascular response threshold, form, or magnitude between the paralyzed and non-paralyzed state, indicating that the cardiovascular response patterns were not secondary to changes in respiration. Bilateral vagotomy abolished the bradycardia responses evoked by hypothalamic stimulation indicating that the cardiodeceleration was mediated by the vagus nerves; vagotomy attenuated tachycardia responses indicating that the responses in part reflected a decrease in vagal restraint. Bradycardia responses to ipsilateral but not contralateral hypothalamic stimulation were attenuated or abolished when examined.
AB - Heart rate and blood pressure response patterns were elicited by relatively low intensity (∼0.2 mA) stimulation (10 s trains; 100 pulses/s; 0.25 ms pulse duration) in different regions of the hypothalamus in anesthetized rabbits. A bradycardia/depressor pattern was elicited from both anterior and posterior stimulating electrode sites in the far lateral hypothalamus. Medial sites including the ventromedial hypothalamus elicited a tachycardia/pressor pattern. A bradycardia/pressor pattern was elicited from both the anterior and posterior hypothalamus at sites between the lateral hypothalamic (bradycardia/depressor) and the medial hypothalamic (tachycardia/pressor) zones. Paralysis by injection of decamethonium in conjunction with artificial ventilation did not reveal systematic differences in cardiovascular response threshold, form, or magnitude between the paralyzed and non-paralyzed state, indicating that the cardiovascular response patterns were not secondary to changes in respiration. Bilateral vagotomy abolished the bradycardia responses evoked by hypothalamic stimulation indicating that the cardiodeceleration was mediated by the vagus nerves; vagotomy attenuated tachycardia responses indicating that the responses in part reflected a decrease in vagal restraint. Bradycardia responses to ipsilateral but not contralateral hypothalamic stimulation were attenuated or abolished when examined.
KW - amygdala central nucleus
KW - blood pressure
KW - heart rate
KW - hypothalamus
KW - intracranial stimulation
KW - rabbits
UR - http://www.scopus.com/inward/record.url?scp=0019837805&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0019837805&partnerID=8YFLogxK
U2 - 10.1016/0165-1838(81)90034-5
DO - 10.1016/0165-1838(81)90034-5
M3 - Article
C2 - 7310047
AN - SCOPUS:0019837805
VL - 4
SP - 301
EP - 317
JO - Autonomic Neuroscience: Basic and Clinical
JF - Autonomic Neuroscience: Basic and Clinical
SN - 1566-0702
IS - 4
ER -