Cardiovascular reactivity and development of preclinical and clinical disease states

Frank A. Treiber, Thomas Kamarck, Neil Schneiderman, David Sheffield, Gaston Kapuku, Teletia Taylor

Research output: Contribution to journalArticle

469 Citations (Scopus)

Abstract

Objective: The objective of this review is to evaluate the evidence for the hypothesis that cardiovascular reactivity can predict the development of preclinical (elevated blood pressure, ventricular remodeling, carotid atherosclerosis) and/or clinical cardiovascular disease states. Methods: A review of the literature was conducted examining prospective studies. Results: Three large epidemiological studies with long-term follow-up periods (20 years or more) have found blood pressure responses to the cold pressor task to be predictive of subsequent essential hypertension in initially normotensive samples. Studies showing less consistent results have tended to use shorter-term follow-up periods. A larger body of literature demonstrates consistent associations between stress-related cardiovascular reactivity and blood pressure elevations in youth over the course of 1 to 6 years; such relationships have not been consistently shown among adult samples. Moderately consistent evidence points to a positive relationship between reactivity and other measures of subclinical disease (increased left ventricular mass and carotid atherosclerosis) among the few prospective studies that have examined these issues to date. A number of additional factors, however, such as baseline levels of disease risk and exposure to psychosocial stress, seem to moderate these relationships. Health status at baseline also seems to moderate the association between reactivity and clinical coronary heart disease in recent reports: two of three existing studies in initially healthy samples show no evidence of a relationship between reactivity and clinical outcomes, whereas three of four studies in samples with preexisting coronary heart disease or essential hypertension show a positive relationship between reactivity and subsequent disease states. Conclusions: There is reasonable evidence to suggest that cardiovascular reactivity can predict the development of some preclinical states (eg, increased left ventricular mass and blood pressure) states and perhaps even new clinical events in some patients with essential hypertension or coronary heart disease. However, much more information is needed concerning moderating and potentially confounding variables before the robustness of the positive relationships can become clinically useful.

Original languageEnglish
Pages (from-to)46-62
Number of pages17
JournalPsychosomatic Medicine
Volume65
Issue number1
StatePublished - Jan 1 2003

Fingerprint

Blood Pressure
Coronary Disease
Carotid Artery Diseases
Prospective Studies
Ventricular Remodeling
Confounding Factors (Epidemiology)
Ventricular Pressure
Health Status
Epidemiologic Studies
Cardiovascular Diseases
Essential Hypertension

Keywords

  • Cardiovascular disease
  • Cardiovascular reactivity
  • Essential hypertension
  • Left ventricular mass
  • Preclinical disease
  • Prediction

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Psychology(all)

Cite this

Treiber, F. A., Kamarck, T., Schneiderman, N., Sheffield, D., Kapuku, G., & Taylor, T. (2003). Cardiovascular reactivity and development of preclinical and clinical disease states. Psychosomatic Medicine, 65(1), 46-62.

Cardiovascular reactivity and development of preclinical and clinical disease states. / Treiber, Frank A.; Kamarck, Thomas; Schneiderman, Neil; Sheffield, David; Kapuku, Gaston; Taylor, Teletia.

In: Psychosomatic Medicine, Vol. 65, No. 1, 01.01.2003, p. 46-62.

Research output: Contribution to journalArticle

Treiber, FA, Kamarck, T, Schneiderman, N, Sheffield, D, Kapuku, G & Taylor, T 2003, 'Cardiovascular reactivity and development of preclinical and clinical disease states', Psychosomatic Medicine, vol. 65, no. 1, pp. 46-62.
Treiber FA, Kamarck T, Schneiderman N, Sheffield D, Kapuku G, Taylor T. Cardiovascular reactivity and development of preclinical and clinical disease states. Psychosomatic Medicine. 2003 Jan 1;65(1):46-62.
Treiber, Frank A. ; Kamarck, Thomas ; Schneiderman, Neil ; Sheffield, David ; Kapuku, Gaston ; Taylor, Teletia. / Cardiovascular reactivity and development of preclinical and clinical disease states. In: Psychosomatic Medicine. 2003 ; Vol. 65, No. 1. pp. 46-62.
@article{63d9e7bfa0d8450692c5d4c8c8116e55,
title = "Cardiovascular reactivity and development of preclinical and clinical disease states",
abstract = "Objective: The objective of this review is to evaluate the evidence for the hypothesis that cardiovascular reactivity can predict the development of preclinical (elevated blood pressure, ventricular remodeling, carotid atherosclerosis) and/or clinical cardiovascular disease states. Methods: A review of the literature was conducted examining prospective studies. Results: Three large epidemiological studies with long-term follow-up periods (20 years or more) have found blood pressure responses to the cold pressor task to be predictive of subsequent essential hypertension in initially normotensive samples. Studies showing less consistent results have tended to use shorter-term follow-up periods. A larger body of literature demonstrates consistent associations between stress-related cardiovascular reactivity and blood pressure elevations in youth over the course of 1 to 6 years; such relationships have not been consistently shown among adult samples. Moderately consistent evidence points to a positive relationship between reactivity and other measures of subclinical disease (increased left ventricular mass and carotid atherosclerosis) among the few prospective studies that have examined these issues to date. A number of additional factors, however, such as baseline levels of disease risk and exposure to psychosocial stress, seem to moderate these relationships. Health status at baseline also seems to moderate the association between reactivity and clinical coronary heart disease in recent reports: two of three existing studies in initially healthy samples show no evidence of a relationship between reactivity and clinical outcomes, whereas three of four studies in samples with preexisting coronary heart disease or essential hypertension show a positive relationship between reactivity and subsequent disease states. Conclusions: There is reasonable evidence to suggest that cardiovascular reactivity can predict the development of some preclinical states (eg, increased left ventricular mass and blood pressure) states and perhaps even new clinical events in some patients with essential hypertension or coronary heart disease. However, much more information is needed concerning moderating and potentially confounding variables before the robustness of the positive relationships can become clinically useful.",
keywords = "Cardiovascular disease, Cardiovascular reactivity, Essential hypertension, Left ventricular mass, Preclinical disease, Prediction",
author = "Treiber, {Frank A.} and Thomas Kamarck and Neil Schneiderman and David Sheffield and Gaston Kapuku and Teletia Taylor",
year = "2003",
month = "1",
day = "1",
language = "English",
volume = "65",
pages = "46--62",
journal = "Psychosomatic Medicine",
issn = "0033-3174",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

TY - JOUR

T1 - Cardiovascular reactivity and development of preclinical and clinical disease states

AU - Treiber, Frank A.

AU - Kamarck, Thomas

AU - Schneiderman, Neil

AU - Sheffield, David

AU - Kapuku, Gaston

AU - Taylor, Teletia

PY - 2003/1/1

Y1 - 2003/1/1

N2 - Objective: The objective of this review is to evaluate the evidence for the hypothesis that cardiovascular reactivity can predict the development of preclinical (elevated blood pressure, ventricular remodeling, carotid atherosclerosis) and/or clinical cardiovascular disease states. Methods: A review of the literature was conducted examining prospective studies. Results: Three large epidemiological studies with long-term follow-up periods (20 years or more) have found blood pressure responses to the cold pressor task to be predictive of subsequent essential hypertension in initially normotensive samples. Studies showing less consistent results have tended to use shorter-term follow-up periods. A larger body of literature demonstrates consistent associations between stress-related cardiovascular reactivity and blood pressure elevations in youth over the course of 1 to 6 years; such relationships have not been consistently shown among adult samples. Moderately consistent evidence points to a positive relationship between reactivity and other measures of subclinical disease (increased left ventricular mass and carotid atherosclerosis) among the few prospective studies that have examined these issues to date. A number of additional factors, however, such as baseline levels of disease risk and exposure to psychosocial stress, seem to moderate these relationships. Health status at baseline also seems to moderate the association between reactivity and clinical coronary heart disease in recent reports: two of three existing studies in initially healthy samples show no evidence of a relationship between reactivity and clinical outcomes, whereas three of four studies in samples with preexisting coronary heart disease or essential hypertension show a positive relationship between reactivity and subsequent disease states. Conclusions: There is reasonable evidence to suggest that cardiovascular reactivity can predict the development of some preclinical states (eg, increased left ventricular mass and blood pressure) states and perhaps even new clinical events in some patients with essential hypertension or coronary heart disease. However, much more information is needed concerning moderating and potentially confounding variables before the robustness of the positive relationships can become clinically useful.

AB - Objective: The objective of this review is to evaluate the evidence for the hypothesis that cardiovascular reactivity can predict the development of preclinical (elevated blood pressure, ventricular remodeling, carotid atherosclerosis) and/or clinical cardiovascular disease states. Methods: A review of the literature was conducted examining prospective studies. Results: Three large epidemiological studies with long-term follow-up periods (20 years or more) have found blood pressure responses to the cold pressor task to be predictive of subsequent essential hypertension in initially normotensive samples. Studies showing less consistent results have tended to use shorter-term follow-up periods. A larger body of literature demonstrates consistent associations between stress-related cardiovascular reactivity and blood pressure elevations in youth over the course of 1 to 6 years; such relationships have not been consistently shown among adult samples. Moderately consistent evidence points to a positive relationship between reactivity and other measures of subclinical disease (increased left ventricular mass and carotid atherosclerosis) among the few prospective studies that have examined these issues to date. A number of additional factors, however, such as baseline levels of disease risk and exposure to psychosocial stress, seem to moderate these relationships. Health status at baseline also seems to moderate the association between reactivity and clinical coronary heart disease in recent reports: two of three existing studies in initially healthy samples show no evidence of a relationship between reactivity and clinical outcomes, whereas three of four studies in samples with preexisting coronary heart disease or essential hypertension show a positive relationship between reactivity and subsequent disease states. Conclusions: There is reasonable evidence to suggest that cardiovascular reactivity can predict the development of some preclinical states (eg, increased left ventricular mass and blood pressure) states and perhaps even new clinical events in some patients with essential hypertension or coronary heart disease. However, much more information is needed concerning moderating and potentially confounding variables before the robustness of the positive relationships can become clinically useful.

KW - Cardiovascular disease

KW - Cardiovascular reactivity

KW - Essential hypertension

KW - Left ventricular mass

KW - Preclinical disease

KW - Prediction

UR - http://www.scopus.com/inward/record.url?scp=12244267665&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=12244267665&partnerID=8YFLogxK

M3 - Article

C2 - 12554815

AN - SCOPUS:12244267665

VL - 65

SP - 46

EP - 62

JO - Psychosomatic Medicine

JF - Psychosomatic Medicine

SN - 0033-3174

IS - 1

ER -