Cardiovascular effects of an intravenous injection of glucagon, 3 mg., were studied in 8 subjects during cardiac catheterization. In each study a prompt effect was noted, with an increase in heart rate, cardiac output, right ventricular dp/dt and right ventricular and systemic systolic pressures. Right ventricular end-diastolic pressure and systemic vascular resistance decreased. It is concluded that glucagon exerts positive inotropic and chronotropic effects upon the heart in man. Further studies are required to determine its proper clinical role and mechanism of action.
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine