Abstract
Treatment of pediatric Hodgkin's disease is largely a success story enabling investigators to explore the late of effects of cancer treatment in long-term survivors. Since mediastinal irradiation is an important component in the management of pediatric Hodgkin's disease, there are potentially significant long-term effects on the cardiovascular system. These are frequently associated with radiation therapy, both with and without chemotherapy. This review article explores the effect of such therapy on the pericardium, myocardium, coronary arteries, branch pulmonary arteries, conduction system as well as the valves. Although early and late effects are identified, their significance remains somewhat unclear. The most severe changes are most often associated with outdated treatment techniques.
| Original language | English |
|---|---|
| Pages (from-to) | 139-144 |
| Number of pages | 6 |
| Journal | Progress in Pediatric Cardiology |
| Volume | 8 |
| Issue number | 3 |
| DOIs | |
| State | Published - Jan 1 1998 |
| Externally published | Yes |
Fingerprint
Keywords
- Anthracycline
- Cardiotoxicity
- Chemotherapy
- Hodgkin's disease
- Late effects
- Radiation-induced heart disease
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Cardiovascular disease in long-term survivors of pediatric Hodgkin's disease. / Cameron, Elizabeth H.; Lipshultz, Steven E; Tarbell, Nancy J.; Mauch, Peter M.
In: Progress in Pediatric Cardiology, Vol. 8, No. 3, 01.01.1998, p. 139-144.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cardiovascular disease in long-term survivors of pediatric Hodgkin's disease
AU - Cameron, Elizabeth H.
AU - Lipshultz, Steven E
AU - Tarbell, Nancy J.
AU - Mauch, Peter M.
PY - 1998/1/1
Y1 - 1998/1/1
N2 - Treatment of pediatric Hodgkin's disease is largely a success story enabling investigators to explore the late of effects of cancer treatment in long-term survivors. Since mediastinal irradiation is an important component in the management of pediatric Hodgkin's disease, there are potentially significant long-term effects on the cardiovascular system. These are frequently associated with radiation therapy, both with and without chemotherapy. This review article explores the effect of such therapy on the pericardium, myocardium, coronary arteries, branch pulmonary arteries, conduction system as well as the valves. Although early and late effects are identified, their significance remains somewhat unclear. The most severe changes are most often associated with outdated treatment techniques.
AB - Treatment of pediatric Hodgkin's disease is largely a success story enabling investigators to explore the late of effects of cancer treatment in long-term survivors. Since mediastinal irradiation is an important component in the management of pediatric Hodgkin's disease, there are potentially significant long-term effects on the cardiovascular system. These are frequently associated with radiation therapy, both with and without chemotherapy. This review article explores the effect of such therapy on the pericardium, myocardium, coronary arteries, branch pulmonary arteries, conduction system as well as the valves. Although early and late effects are identified, their significance remains somewhat unclear. The most severe changes are most often associated with outdated treatment techniques.
KW - Anthracycline
KW - Cardiotoxicity
KW - Chemotherapy
KW - Hodgkin's disease
KW - Late effects
KW - Radiation-induced heart disease
UR - http://www.scopus.com/inward/record.url?scp=0031894370&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031894370&partnerID=8YFLogxK
U2 - 10.1016/S1058-9813(98)00009-5
DO - 10.1016/S1058-9813(98)00009-5
M3 - Article
VL - 8
SP - 139
EP - 144
JO - Progress in Pediatric Cardiology
JF - Progress in Pediatric Cardiology
SN - 1058-9813
IS - 3
ER -