Cardiovascular disease in long-term survivors of pediatric Hodgkin's disease

Elizabeth H. Cameron, Steven E. Lipshultz, Nancy J. Tarbell, Peter M. Mauch

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Treatment of pediatric Hodgkin's disease is largely a success story enabling investigators to explore the late of effects of cancer treatment in long-term survivors. Since mediastinal irradiation is an important component in the management of pediatric Hodgkin's disease, there are potentially significant long-term effects on the cardiovascular system. These are frequently associated with radiation therapy, both with and without chemotherapy. This review article explores the effect of such therapy on the pericardium, myocardium, coronary arteries, branch pulmonary arteries, conduction system as well as the valves. Although early and late effects are identified, their significance remains somewhat unclear. The most severe changes are most often associated with outdated treatment techniques.

Original languageEnglish (US)
Pages (from-to)139-144
Number of pages6
JournalProgress in Pediatric Cardiology
Volume8
Issue number3
DOIs
StatePublished - Jan 1 1998

Keywords

  • Anthracycline
  • Cardiotoxicity
  • Chemotherapy
  • Hodgkin's disease
  • Late effects
  • Radiation-induced heart disease

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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