Cardiovascular disease and toxicities related to HIV infection and its therapies

Karolina M. Zareba, Tracie L. Miller, Steven E. Lipshultz

Research output: Contribution to journalReview articlepeer-review

15 Scopus citations


Cardiovascular manifestations of HIV vary according to disease stage, treatment regimen and geographical location. Common cardiac complications of HIV disease in patients off highly active antiretroviral therapy (HAART) include dilated cardiomyopathy, myocarditis, pericardial effusion, endocarditis, pulmonary hypertension and non-antiretroviral drug-related cardiotoxicity. However, with the introduction of HAART that has substantially modified the course of HIV disease by lengthening survival, additional cardiovascular consequences are a result of the metabolic syndrome with a propensity toward hyperlipidaemia and atherosclerotic heart disease. Because most of the world's HIV-infected patients have not been treated with HAART, the principal HIV-associated cardiovascular manifestations of patients off HAART are reviewed and new knowledge about the prevalence, pathogenesis and treatment in the HAART era are emphasised in this review. Exercise, a nonpharmacological approach to treating HAART-associated metabolic syndrome, is also discussed.

Original languageEnglish (US)
Pages (from-to)1017-1025
Number of pages9
JournalExpert Opinion on Drug Safety
Issue number6
StatePublished - Nov 2005


  • AIDS
  • Cardiomyopathy
  • Cardiotoxicity
  • Dyslipidaemia
  • Exercise
  • Highly active antiretroviral theraphy (HAART)
  • HIV

ASJC Scopus subject areas

  • Pharmacology


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