Cardiovascular disease and toxicities related to HIV infection and its therapies

Karolina M. Zareba, Tracie L. Miller, Steven E. Lipshultz

Research output: Contribution to journalReview article

15 Scopus citations

Abstract

Cardiovascular manifestations of HIV vary according to disease stage, treatment regimen and geographical location. Common cardiac complications of HIV disease in patients off highly active antiretroviral therapy (HAART) include dilated cardiomyopathy, myocarditis, pericardial effusion, endocarditis, pulmonary hypertension and non-antiretroviral drug-related cardiotoxicity. However, with the introduction of HAART that has substantially modified the course of HIV disease by lengthening survival, additional cardiovascular consequences are a result of the metabolic syndrome with a propensity toward hyperlipidaemia and atherosclerotic heart disease. Because most of the world's HIV-infected patients have not been treated with HAART, the principal HIV-associated cardiovascular manifestations of patients off HAART are reviewed and new knowledge about the prevalence, pathogenesis and treatment in the HAART era are emphasised in this review. Exercise, a nonpharmacological approach to treating HAART-associated metabolic syndrome, is also discussed.

Original languageEnglish (US)
Pages (from-to)1017-1025
Number of pages9
JournalExpert Opinion on Drug Safety
Volume4
Issue number6
DOIs
StatePublished - Nov 1 2005

Keywords

  • AIDS
  • Cardiomyopathy
  • Cardiotoxicity
  • Dyslipidaemia
  • Exercise
  • Highly active antiretroviral theraphy (HAART)
  • HIV

ASJC Scopus subject areas

  • Pharmacology

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