Cardiotoxic effects of astemizole overdose in children

James F. Wiley, Marcia L. Gelber, Fred M. Henretig, Catherine C. Wiley, Satinder K Sandhu, John Loiselle

Research output: Contribution to journalArticle

70 Citations (Scopus)

Abstract

Astemizole, a nonsedating antihistamine, caused a prolonged corrected QT interval, ventricular dysrhythmias, and atrioventricular heart block after overdose in five children. Cardiotoxic effects lasted an averaged of 2 1/2 days. Children poisoned with astemizole need emergent medical evaluation, a 12-lead electro-cardiogram with calculation of the corrected QT interval, and continuous cardiac monitoring for 24 hours.

Original languageEnglish
Pages (from-to)799-802
Number of pages4
JournalThe Journal of pediatrics
Volume120
Issue number5
DOIs
StatePublished - Jan 1 1992
Externally publishedYes

Fingerprint

Astemizole
Heart Block
Atrioventricular Block
Histamine Antagonists

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Wiley, J. F., Gelber, M. L., Henretig, F. M., Wiley, C. C., Sandhu, S. K., & Loiselle, J. (1992). Cardiotoxic effects of astemizole overdose in children. The Journal of pediatrics, 120(5), 799-802. https://doi.org/10.1016/S0022-3476(05)80252-5

Cardiotoxic effects of astemizole overdose in children. / Wiley, James F.; Gelber, Marcia L.; Henretig, Fred M.; Wiley, Catherine C.; Sandhu, Satinder K; Loiselle, John.

In: The Journal of pediatrics, Vol. 120, No. 5, 01.01.1992, p. 799-802.

Research output: Contribution to journalArticle

Wiley, JF, Gelber, ML, Henretig, FM, Wiley, CC, Sandhu, SK & Loiselle, J 1992, 'Cardiotoxic effects of astemizole overdose in children', The Journal of pediatrics, vol. 120, no. 5, pp. 799-802. https://doi.org/10.1016/S0022-3476(05)80252-5
Wiley, James F. ; Gelber, Marcia L. ; Henretig, Fred M. ; Wiley, Catherine C. ; Sandhu, Satinder K ; Loiselle, John. / Cardiotoxic effects of astemizole overdose in children. In: The Journal of pediatrics. 1992 ; Vol. 120, No. 5. pp. 799-802.
@article{461cb00c5cbb4ff9a9453311b316ac53,
title = "Cardiotoxic effects of astemizole overdose in children",
abstract = "Astemizole, a nonsedating antihistamine, caused a prolonged corrected QT interval, ventricular dysrhythmias, and atrioventricular heart block after overdose in five children. Cardiotoxic effects lasted an averaged of 2 1/2 days. Children poisoned with astemizole need emergent medical evaluation, a 12-lead electro-cardiogram with calculation of the corrected QT interval, and continuous cardiac monitoring for 24 hours.",
author = "Wiley, {James F.} and Gelber, {Marcia L.} and Henretig, {Fred M.} and Wiley, {Catherine C.} and Sandhu, {Satinder K} and John Loiselle",
year = "1992",
month = "1",
day = "1",
doi = "10.1016/S0022-3476(05)80252-5",
language = "English",
volume = "120",
pages = "799--802",
journal = "Journal of Pediatrics",
issn = "0022-3476",
publisher = "Mosby Inc.",
number = "5",

}

TY - JOUR

T1 - Cardiotoxic effects of astemizole overdose in children

AU - Wiley, James F.

AU - Gelber, Marcia L.

AU - Henretig, Fred M.

AU - Wiley, Catherine C.

AU - Sandhu, Satinder K

AU - Loiselle, John

PY - 1992/1/1

Y1 - 1992/1/1

N2 - Astemizole, a nonsedating antihistamine, caused a prolonged corrected QT interval, ventricular dysrhythmias, and atrioventricular heart block after overdose in five children. Cardiotoxic effects lasted an averaged of 2 1/2 days. Children poisoned with astemizole need emergent medical evaluation, a 12-lead electro-cardiogram with calculation of the corrected QT interval, and continuous cardiac monitoring for 24 hours.

AB - Astemizole, a nonsedating antihistamine, caused a prolonged corrected QT interval, ventricular dysrhythmias, and atrioventricular heart block after overdose in five children. Cardiotoxic effects lasted an averaged of 2 1/2 days. Children poisoned with astemizole need emergent medical evaluation, a 12-lead electro-cardiogram with calculation of the corrected QT interval, and continuous cardiac monitoring for 24 hours.

UR - http://www.scopus.com/inward/record.url?scp=0026603816&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026603816&partnerID=8YFLogxK

U2 - 10.1016/S0022-3476(05)80252-5

DO - 10.1016/S0022-3476(05)80252-5

M3 - Article

VL - 120

SP - 799

EP - 802

JO - Journal of Pediatrics

JF - Journal of Pediatrics

SN - 0022-3476

IS - 5

ER -