Cardiotoxic effects of astemizole overdose in children

James F. Wiley, Marcia L. Gelber, Fred M. Henretig, Catherine C. Wiley, Satinder Sandhu, John Loiselle

Research output: Contribution to journalArticlepeer-review

75 Scopus citations


Astemizole, a nonsedating antihistamine, caused a prolonged corrected QT interval, ventricular dysrhythmias, and atrioventricular heart block after overdose in five children. Cardiotoxic effects lasted an averaged of 2 1/2 days. Children poisoned with astemizole need emergent medical evaluation, a 12-lead electro-cardiogram with calculation of the corrected QT interval, and continuous cardiac monitoring for 24 hours.

Original languageEnglish (US)
Pages (from-to)799-802
Number of pages4
JournalThe Journal of Pediatrics
Issue number5
StatePublished - May 1992
Externally publishedYes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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