Cardiotoxic effects of astemizole overdose in children

James F. Wiley; Marcia L. Gelber; Fred M. Henretig; Catherine C. Wiley; Satinder Sandhu; John Loiselle

doi:10.1016/S0022-3476(05)80252-5

Cardiotoxic effects of astemizole overdose in children

James F. Wiley, Marcia L. Gelber, Fred M. Henretig, Catherine C. Wiley, Satinder Sandhu, John Loiselle

Research output: Contribution to journal › Article › peer-review

71 Scopus citations

Abstract

Astemizole, a nonsedating antihistamine, caused a prolonged corrected QT interval, ventricular dysrhythmias, and atrioventricular heart block after overdose in five children. Cardiotoxic effects lasted an averaged of 2 1/2 days. Children poisoned with astemizole need emergent medical evaluation, a 12-lead electro-cardiogram with calculation of the corrected QT interval, and continuous cardiac monitoring for 24 hours.

Original language	English (US)
Pages (from-to)	799-802
Number of pages	4
Journal	The Journal of Pediatrics
Volume	120
Issue number	5
DOIs	https://doi.org/10.1016/S0022-3476(05)80252-5
State	Published - May 1992
Externally published	Yes

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health

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title = "Cardiotoxic effects of astemizole overdose in children",

abstract = "Astemizole, a nonsedating antihistamine, caused a prolonged corrected QT interval, ventricular dysrhythmias, and atrioventricular heart block after overdose in five children. Cardiotoxic effects lasted an averaged of 2 1/2 days. Children poisoned with astemizole need emergent medical evaluation, a 12-lead electro-cardiogram with calculation of the corrected QT interval, and continuous cardiac monitoring for 24 hours.",

author = "Wiley, {James F.} and Gelber, {Marcia L.} and Henretig, {Fred M.} and Wiley, {Catherine C.} and Satinder Sandhu and John Loiselle",

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AU - Gelber, Marcia L.

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AU - Sandhu, Satinder

AU - Loiselle, John

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AB - Astemizole, a nonsedating antihistamine, caused a prolonged corrected QT interval, ventricular dysrhythmias, and atrioventricular heart block after overdose in five children. Cardiotoxic effects lasted an averaged of 2 1/2 days. Children poisoned with astemizole need emergent medical evaluation, a 12-lead electro-cardiogram with calculation of the corrected QT interval, and continuous cardiac monitoring for 24 hours.

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