Abstract
Astemizole, a nonsedating antihistamine, caused a prolonged corrected QT interval, ventricular dysrhythmias, and atrioventricular heart block after overdose in five children. Cardiotoxic effects lasted an averaged of 2 1/2 days. Children poisoned with astemizole need emergent medical evaluation, a 12-lead electro-cardiogram with calculation of the corrected QT interval, and continuous cardiac monitoring for 24 hours.
| Original language | English |
|---|---|
| Pages (from-to) | 799-802 |
| Number of pages | 4 |
| Journal | The Journal of pediatrics |
| Volume | 120 |
| Issue number | 5 |
| DOIs | |
| State | Published - Jan 1 1992 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
Cite this
Cardiotoxic effects of astemizole overdose in children. / Wiley, James F.; Gelber, Marcia L.; Henretig, Fred M.; Wiley, Catherine C.; Sandhu, Satinder K; Loiselle, John.
In: The Journal of pediatrics, Vol. 120, No. 5, 01.01.1992, p. 799-802.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cardiotoxic effects of astemizole overdose in children
AU - Wiley, James F.
AU - Gelber, Marcia L.
AU - Henretig, Fred M.
AU - Wiley, Catherine C.
AU - Sandhu, Satinder K
AU - Loiselle, John
PY - 1992/1/1
Y1 - 1992/1/1
N2 - Astemizole, a nonsedating antihistamine, caused a prolonged corrected QT interval, ventricular dysrhythmias, and atrioventricular heart block after overdose in five children. Cardiotoxic effects lasted an averaged of 2 1/2 days. Children poisoned with astemizole need emergent medical evaluation, a 12-lead electro-cardiogram with calculation of the corrected QT interval, and continuous cardiac monitoring for 24 hours.
AB - Astemizole, a nonsedating antihistamine, caused a prolonged corrected QT interval, ventricular dysrhythmias, and atrioventricular heart block after overdose in five children. Cardiotoxic effects lasted an averaged of 2 1/2 days. Children poisoned with astemizole need emergent medical evaluation, a 12-lead electro-cardiogram with calculation of the corrected QT interval, and continuous cardiac monitoring for 24 hours.
UR - http://www.scopus.com/inward/record.url?scp=0026603816&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026603816&partnerID=8YFLogxK
U2 - 10.1016/S0022-3476(05)80252-5
DO - 10.1016/S0022-3476(05)80252-5
M3 - Article
C2 - 1578320
AN - SCOPUS:0026603816
VL - 120
SP - 799
EP - 802
JO - Journal of Pediatrics
JF - Journal of Pediatrics
SN - 0022-3476
IS - 5
ER -