Cardiopulmonary bypass after prolonged cardiac arrest in dogs

Ernesto Pretto, Peter Safar, Reisuke Saito, William Stezoski, Sheryl Kelsey

Research output: Contribution to journalArticlepeer-review

55 Scopus citations


Ventricular fibrillation (VF) cardiac arrest of more than ten minutes can be survived by cerebral neurons, but restoration of spontaneous circulation (ROSC) by external CPR is unreliable. Cardiopulmonary bypass (CPB) permits control of pressure, flow, oxygenation, temperature, and composition of blood. After 121/2 minutes of normothermic VF cardiac arrest, CPB was used as a research tool for reperfusion and assisted circulation for two hours in ten dogs without thoracotomy, with plasma substitute priming, and without preceding CPR (a deliberately non clinical scenario). Recovery was compared with that in ten control dogs in which standard CPR with advanced life support (ALS) for up to 30 minutes was used to achieve ROSC. Both groups subsequently had blood pressure, blood gases, ventilation, and other parameters controlled for 20 hours, and intensive therapy to 72 hours. CPB achieved ROSC more successfully (ten of ten vs six of ten controls) (P < .05), and more rapidly, with fewer defibrillation attempts and with less epinephrine (P < .05). CPB improved 72-hour survival (seven of ten vs two of ten controls) (P = .025). Between two and 24 hours, of those with ROSC, intractable cardiogenic shock killed four of six control dogs (NS). CPB was followed by fewer arrhythmias. CPB increased recovery of consciousness (five of ten CPB vs zero of six controls with ROSC) (P = .037), but achieved neurologic normality in only one of ten. Cardiac arrest and CPB (without CPR) resulted in less myocardial morphologic damage than did standard CPR (P < .025). We conclude that after prolonged cardiac arrest, reperfusior, with CPB increases cardiovascular resuscitability and thereby survival compared to standard CPR and advanced life support. Cerebral recovery, however, requires more than CPB. CPB should be explored in a CPR animal model with a clinically realistic scenario.

Original languageEnglish (US)
Pages (from-to)611-619
Number of pages9
JournalAnnals of Emergency Medicine
Issue number6
StatePublished - Jun 1987


  • bypass, cardiopulmonary, canine

ASJC Scopus subject areas

  • Emergency Medicine


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