Abstract
Purpose: The purposes of the present study were to assess the effects of a 12-wk laboratory based aerobic exercise program on cardiopulmonary function, CD4 cell count, and physician-assessed health status among symptomatic pre-AIDS HIV-infected individuals (N = 28) and to assess the degree to which ill health was associated with exercise relapse. Methods: Responses to graded exercise test, physician-assessed health status, and CD4 cell counts were determined at baseline and 12-wk follow-up for participants randomly assigned to exercise or control conditions, and reasons for exercise noncompliance were recorded. Results: Approximately 61% of exercise-assigned participants complied (> 50% attendance) with the exercise program, and analyses of exercise relapse data indicated that obesity and smoking status, but not exercise-associated illness, differentiated compliant from noncompliant exercisers. Compliant exercisers significantly improved peak oxygen consumption (V̇O(2peak); 12%), oxygen pulse (O(2pulse); 13%), tidal volume (TV; 8%), ventilation (V̇E; 17%), and leg power (25%) to a greater degree than control participants and noncompliant exercisers (all P < 0.05). Although no group differences in health status were found, a significant interaction effect indicated that noncompliant exercisers' CD4 cells declined (18%) significantly, whereas compliant exercisers' cell counts significantly increased (13%; P < 0.05). Conclusion: We conclude that although aerobic exercise can improve cardiopulmonary functioning in symptomatic HIV-infected individuals with minimal health risks, attention to factors associated with exercise adherence is warranted.
| Original language | English |
|---|---|
| Pages (from-to) | 973-979 |
| Number of pages | 7 |
| Journal | Medicine and Science in Sports and Exercise |
| Volume | 31 |
| Issue number | 7 |
| DOIs | |
| State | Published - Jul 17 1999 |
| Externally published | Yes |
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Keywords
- Aerobic Exercise
- AIDS
- Compliance
- Immune System
ASJC Scopus subject areas
- Public Health, Environmental and Occupational Health
- Physical Therapy, Sports Therapy and Rehabilitation
- Orthopedics and Sports Medicine
Cite this
Cardiopulmonary and CD4 cell changes in response to exercise training early symptomatic HIV infection. / Perna, Frank M.; Laperriere, Arthur; Klimas, Nancy; Ironson, Gail; Perry, Arlette; Pavone, Jean; Goldstein, Alison; Majors, Pat; Makemson, David; Talutto, Craig; Schneiderman, Neil; Fletcher, Mary Ann; Meijer, Onno G.; Koppes, Lando.
In: Medicine and Science in Sports and Exercise, Vol. 31, No. 7, 17.07.1999, p. 973-979.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cardiopulmonary and CD4 cell changes in response to exercise training early symptomatic HIV infection
AU - Perna, Frank M.
AU - Laperriere, Arthur
AU - Klimas, Nancy
AU - Ironson, Gail
AU - Perry, Arlette
AU - Pavone, Jean
AU - Goldstein, Alison
AU - Majors, Pat
AU - Makemson, David
AU - Talutto, Craig
AU - Schneiderman, Neil
AU - Fletcher, Mary Ann
AU - Meijer, Onno G.
AU - Koppes, Lando
PY - 1999/7/17
Y1 - 1999/7/17
N2 - Purpose: The purposes of the present study were to assess the effects of a 12-wk laboratory based aerobic exercise program on cardiopulmonary function, CD4 cell count, and physician-assessed health status among symptomatic pre-AIDS HIV-infected individuals (N = 28) and to assess the degree to which ill health was associated with exercise relapse. Methods: Responses to graded exercise test, physician-assessed health status, and CD4 cell counts were determined at baseline and 12-wk follow-up for participants randomly assigned to exercise or control conditions, and reasons for exercise noncompliance were recorded. Results: Approximately 61% of exercise-assigned participants complied (> 50% attendance) with the exercise program, and analyses of exercise relapse data indicated that obesity and smoking status, but not exercise-associated illness, differentiated compliant from noncompliant exercisers. Compliant exercisers significantly improved peak oxygen consumption (V̇O(2peak); 12%), oxygen pulse (O(2pulse); 13%), tidal volume (TV; 8%), ventilation (V̇E; 17%), and leg power (25%) to a greater degree than control participants and noncompliant exercisers (all P < 0.05). Although no group differences in health status were found, a significant interaction effect indicated that noncompliant exercisers' CD4 cells declined (18%) significantly, whereas compliant exercisers' cell counts significantly increased (13%; P < 0.05). Conclusion: We conclude that although aerobic exercise can improve cardiopulmonary functioning in symptomatic HIV-infected individuals with minimal health risks, attention to factors associated with exercise adherence is warranted.
AB - Purpose: The purposes of the present study were to assess the effects of a 12-wk laboratory based aerobic exercise program on cardiopulmonary function, CD4 cell count, and physician-assessed health status among symptomatic pre-AIDS HIV-infected individuals (N = 28) and to assess the degree to which ill health was associated with exercise relapse. Methods: Responses to graded exercise test, physician-assessed health status, and CD4 cell counts were determined at baseline and 12-wk follow-up for participants randomly assigned to exercise or control conditions, and reasons for exercise noncompliance were recorded. Results: Approximately 61% of exercise-assigned participants complied (> 50% attendance) with the exercise program, and analyses of exercise relapse data indicated that obesity and smoking status, but not exercise-associated illness, differentiated compliant from noncompliant exercisers. Compliant exercisers significantly improved peak oxygen consumption (V̇O(2peak); 12%), oxygen pulse (O(2pulse); 13%), tidal volume (TV; 8%), ventilation (V̇E; 17%), and leg power (25%) to a greater degree than control participants and noncompliant exercisers (all P < 0.05). Although no group differences in health status were found, a significant interaction effect indicated that noncompliant exercisers' CD4 cells declined (18%) significantly, whereas compliant exercisers' cell counts significantly increased (13%; P < 0.05). Conclusion: We conclude that although aerobic exercise can improve cardiopulmonary functioning in symptomatic HIV-infected individuals with minimal health risks, attention to factors associated with exercise adherence is warranted.
KW - Aerobic Exercise
KW - AIDS
KW - Compliance
KW - Immune System
UR - http://www.scopus.com/inward/record.url?scp=0033018750&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033018750&partnerID=8YFLogxK
U2 - 10.1097/00005768-199907000-00009
DO - 10.1097/00005768-199907000-00009
M3 - Article
C2 - 10416558
AN - SCOPUS:0033018750
VL - 31
SP - 973
EP - 979
JO - Medicine and Science in Sports and Exercise
JF - Medicine and Science in Sports and Exercise
SN - 0195-9131
IS - 7
ER -