Cardiopulmonary and CD4 cell changes in response to exercise training early symptomatic HIV infection

Frank M. Perna; Arthur Laperriere; Nancy Klimas; Gail Ironson; Arlette Perry; Jean Pavone; Alison Goldstein; Pat Majors; David Makemson; Craig Talutto; Neil Schneiderman; Mary Ann Fletcher; Onno G. Meijer; Lando Koppes

doi:10.1097/00005768-199907000-00009

Cardiopulmonary and CD4 cell changes in response to exercise training early symptomatic HIV infection

Frank M. Perna, Arthur Laperriere, Nancy Klimas, Gail Ironson, Arlette Perry, Jean Pavone, Alison Goldstein, Pat Majors, David Makemson, Craig Talutto, Neil Schneiderman, Mary Ann Fletcher, Onno G. Meijer, Lando Koppes

67 Scopus citations

Original language	English
Pages (from-to)	973-979
Number of pages	7
Journal	Medicine and Science in Sports and Exercise
Volume	31
Issue number	7
DOIs	https://doi.org/10.1097/00005768-199907000-00009
State	Published - Jul 17 1999
Externally published	Yes

Keywords

Aerobic Exercise
AIDS
Compliance
Immune System

ASJC Scopus subject areas

Public Health, Environmental and Occupational Health
Physical Therapy, Sports Therapy and Rehabilitation
Orthopedics and Sports Medicine

Cite this

Perna, F. M., Laperriere, A., Klimas, N., Ironson, G., Perry, A., Pavone, J., Goldstein, A., Majors, P., Makemson, D., Talutto, C., Schneiderman, N., Fletcher, M. A., Meijer, O. G., & Koppes, L. (1999). Cardiopulmonary and CD4 cell changes in response to exercise training early symptomatic HIV infection. Medicine and Science in Sports and Exercise, 31(7), 973-979. https://doi.org/10.1097/00005768-199907000-00009

Perna, FM, Laperriere, A, Klimas, N, Ironson, G , Perry, A, Pavone, J, Goldstein, A, Majors, P, Makemson, D, Talutto, C, Schneiderman, N, Fletcher, MA, Meijer, OG & Koppes, L 1999, 'Cardiopulmonary and CD4 cell changes in response to exercise training early symptomatic HIV infection', Medicine and Science in Sports and Exercise, vol. 31, no. 7, pp. 973-979. https://doi.org/10.1097/00005768-199907000-00009

Perna, Frank M. ; Laperriere, Arthur ; Klimas, Nancy ; Ironson, Gail ; Perry, Arlette ; Pavone, Jean ; Goldstein, Alison ; Majors, Pat ; Makemson, David ; Talutto, Craig ; Schneiderman, Neil ; Fletcher, Mary Ann ; Meijer, Onno G. ; Koppes, Lando. / Cardiopulmonary and CD4 cell changes in response to exercise training early symptomatic HIV infection. In: Medicine and Science in Sports and Exercise. 1999 ; Vol. 31, No. 7. pp. 973-979.

@article{1c30eda430614f1091a976348388e1ad,

title = "Cardiopulmonary and CD4 cell changes in response to exercise training early symptomatic HIV infection",

abstract = "Purpose: The purposes of the present study were to assess the effects of a 12-wk laboratory based aerobic exercise program on cardiopulmonary function, CD4 cell count, and physician-assessed health status among symptomatic pre-AIDS HIV-infected individuals (N = 28) and to assess the degree to which ill health was associated with exercise relapse. Methods: Responses to graded exercise test, physician-assessed health status, and CD4 cell counts were determined at baseline and 12-wk follow-up for participants randomly assigned to exercise or control conditions, and reasons for exercise noncompliance were recorded. Results: Approximately 61% of exercise-assigned participants complied (> 50% attendance) with the exercise program, and analyses of exercise relapse data indicated that obesity and smoking status, but not exercise-associated illness, differentiated compliant from noncompliant exercisers. Compliant exercisers significantly improved peak oxygen consumption ({\.V}O(2peak); 12%), oxygen pulse (O(2pulse); 13%), tidal volume (TV; 8%), ventilation ({\.V}E; 17%), and leg power (25%) to a greater degree than control participants and noncompliant exercisers (all P < 0.05). Although no group differences in health status were found, a significant interaction effect indicated that noncompliant exercisers' CD4 cells declined (18%) significantly, whereas compliant exercisers' cell counts significantly increased (13%; P < 0.05). Conclusion: We conclude that although aerobic exercise can improve cardiopulmonary functioning in symptomatic HIV-infected individuals with minimal health risks, attention to factors associated with exercise adherence is warranted.",

keywords = "Aerobic Exercise, AIDS, Compliance, Immune System",

author = "Perna, {Frank M.} and Arthur Laperriere and Nancy Klimas and Gail Ironson and Arlette Perry and Jean Pavone and Alison Goldstein and Pat Majors and David Makemson and Craig Talutto and Neil Schneiderman and Fletcher, {Mary Ann} and Meijer, {Onno G.} and Lando Koppes",

year = "1999",

month = jul

day = "17",

doi = "10.1097/00005768-199907000-00009",

language = "English",

volume = "31",

pages = "973--979",

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T1 - Cardiopulmonary and CD4 cell changes in response to exercise training early symptomatic HIV infection

AU - Perna, Frank M.

AU - Laperriere, Arthur

AU - Klimas, Nancy

AU - Ironson, Gail

AU - Perry, Arlette

AU - Pavone, Jean

AU - Goldstein, Alison

AU - Majors, Pat

AU - Makemson, David

AU - Talutto, Craig

AU - Schneiderman, Neil

AU - Fletcher, Mary Ann

AU - Meijer, Onno G.

AU - Koppes, Lando

PY - 1999/7/17

Y1 - 1999/7/17

N2 - Purpose: The purposes of the present study were to assess the effects of a 12-wk laboratory based aerobic exercise program on cardiopulmonary function, CD4 cell count, and physician-assessed health status among symptomatic pre-AIDS HIV-infected individuals (N = 28) and to assess the degree to which ill health was associated with exercise relapse. Methods: Responses to graded exercise test, physician-assessed health status, and CD4 cell counts were determined at baseline and 12-wk follow-up for participants randomly assigned to exercise or control conditions, and reasons for exercise noncompliance were recorded. Results: Approximately 61% of exercise-assigned participants complied (> 50% attendance) with the exercise program, and analyses of exercise relapse data indicated that obesity and smoking status, but not exercise-associated illness, differentiated compliant from noncompliant exercisers. Compliant exercisers significantly improved peak oxygen consumption (V̇O(2peak); 12%), oxygen pulse (O(2pulse); 13%), tidal volume (TV; 8%), ventilation (V̇E; 17%), and leg power (25%) to a greater degree than control participants and noncompliant exercisers (all P < 0.05). Although no group differences in health status were found, a significant interaction effect indicated that noncompliant exercisers' CD4 cells declined (18%) significantly, whereas compliant exercisers' cell counts significantly increased (13%; P < 0.05). Conclusion: We conclude that although aerobic exercise can improve cardiopulmonary functioning in symptomatic HIV-infected individuals with minimal health risks, attention to factors associated with exercise adherence is warranted.

AB - Purpose: The purposes of the present study were to assess the effects of a 12-wk laboratory based aerobic exercise program on cardiopulmonary function, CD4 cell count, and physician-assessed health status among symptomatic pre-AIDS HIV-infected individuals (N = 28) and to assess the degree to which ill health was associated with exercise relapse. Methods: Responses to graded exercise test, physician-assessed health status, and CD4 cell counts were determined at baseline and 12-wk follow-up for participants randomly assigned to exercise or control conditions, and reasons for exercise noncompliance were recorded. Results: Approximately 61% of exercise-assigned participants complied (> 50% attendance) with the exercise program, and analyses of exercise relapse data indicated that obesity and smoking status, but not exercise-associated illness, differentiated compliant from noncompliant exercisers. Compliant exercisers significantly improved peak oxygen consumption (V̇O(2peak); 12%), oxygen pulse (O(2pulse); 13%), tidal volume (TV; 8%), ventilation (V̇E; 17%), and leg power (25%) to a greater degree than control participants and noncompliant exercisers (all P < 0.05). Although no group differences in health status were found, a significant interaction effect indicated that noncompliant exercisers' CD4 cells declined (18%) significantly, whereas compliant exercisers' cell counts significantly increased (13%; P < 0.05). Conclusion: We conclude that although aerobic exercise can improve cardiopulmonary functioning in symptomatic HIV-infected individuals with minimal health risks, attention to factors associated with exercise adherence is warranted.

KW - Aerobic Exercise

KW - AIDS

KW - Compliance

KW - Immune System

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