Cardiopulmonary and CD4 cell changes in response to exercise training early symptomatic HIV infection

Frank M. Perna, Arthur Laperriere, Nancy Klimas, Gail Ironson, Arlette Perry, Jean Pavone, Alison Goldstein, Pat Majors, David Makemson, Craig Talutto, Neil Schneiderman, Mary Ann Fletcher, Onno G. Meijer, Lando Koppes

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

Purpose: The purposes of the present study were to assess the effects of a 12-wk laboratory based aerobic exercise program on cardiopulmonary function, CD4 cell count, and physician-assessed health status among symptomatic pre-AIDS HIV-infected individuals (N = 28) and to assess the degree to which ill health was associated with exercise relapse. Methods: Responses to graded exercise test, physician-assessed health status, and CD4 cell counts were determined at baseline and 12-wk follow-up for participants randomly assigned to exercise or control conditions, and reasons for exercise noncompliance were recorded. Results: Approximately 61% of exercise-assigned participants complied (> 50% attendance) with the exercise program, and analyses of exercise relapse data indicated that obesity and smoking status, but not exercise-associated illness, differentiated compliant from noncompliant exercisers. Compliant exercisers significantly improved peak oxygen consumption (V̇O(2peak); 12%), oxygen pulse (O(2pulse); 13%), tidal volume (TV; 8%), ventilation (V̇E; 17%), and leg power (25%) to a greater degree than control participants and noncompliant exercisers (all P < 0.05). Although no group differences in health status were found, a significant interaction effect indicated that noncompliant exercisers' CD4 cells declined (18%) significantly, whereas compliant exercisers' cell counts significantly increased (13%; P < 0.05). Conclusion: We conclude that although aerobic exercise can improve cardiopulmonary functioning in symptomatic HIV-infected individuals with minimal health risks, attention to factors associated with exercise adherence is warranted.

Original languageEnglish
Pages (from-to)973-979
Number of pages7
JournalMedicine and Science in Sports and Exercise
Volume31
Issue number7
DOIs
StatePublished - Jul 17 1999
Externally publishedYes

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HIV Infections
Exercise
Health Status
CD4 Lymphocyte Count
HIV
Physicians
Recurrence
Tidal Volume
Health
Exercise Test
Oxygen Consumption
Ventilation
Leg
Acquired Immunodeficiency Syndrome
Obesity
Cell Count
Smoking
Oxygen

Keywords

  • Aerobic Exercise
  • AIDS
  • Compliance
  • Immune System

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Physical Therapy, Sports Therapy and Rehabilitation
  • Orthopedics and Sports Medicine

Cite this

Cardiopulmonary and CD4 cell changes in response to exercise training early symptomatic HIV infection. / Perna, Frank M.; Laperriere, Arthur; Klimas, Nancy; Ironson, Gail; Perry, Arlette; Pavone, Jean; Goldstein, Alison; Majors, Pat; Makemson, David; Talutto, Craig; Schneiderman, Neil; Fletcher, Mary Ann; Meijer, Onno G.; Koppes, Lando.

In: Medicine and Science in Sports and Exercise, Vol. 31, No. 7, 17.07.1999, p. 973-979.

Research output: Contribution to journalArticle

Perna, FM, Laperriere, A, Klimas, N, Ironson, G, Perry, A, Pavone, J, Goldstein, A, Majors, P, Makemson, D, Talutto, C, Schneiderman, N, Fletcher, MA, Meijer, OG & Koppes, L 1999, 'Cardiopulmonary and CD4 cell changes in response to exercise training early symptomatic HIV infection', Medicine and Science in Sports and Exercise, vol. 31, no. 7, pp. 973-979. https://doi.org/10.1097/00005768-199907000-00009
Perna, Frank M. ; Laperriere, Arthur ; Klimas, Nancy ; Ironson, Gail ; Perry, Arlette ; Pavone, Jean ; Goldstein, Alison ; Majors, Pat ; Makemson, David ; Talutto, Craig ; Schneiderman, Neil ; Fletcher, Mary Ann ; Meijer, Onno G. ; Koppes, Lando. / Cardiopulmonary and CD4 cell changes in response to exercise training early symptomatic HIV infection. In: Medicine and Science in Sports and Exercise. 1999 ; Vol. 31, No. 7. pp. 973-979.
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