We report about clinical experiences with the cardioplegia according to Bretschneider, combined with deep selective hypothermia of the heart in 44 patients. Before, during and after cardioplegia we made biopsies from the left ventricle of 6 patients for electron-microscopical examinations. Besides the mitochondrial changes already known we saw a break-down of the nexuses. We discuss the importance of these changes for the action of the cardioplegia. Both changes seemed to be reversible. The clinical results and the immediate and later postoperative follow-up demonstrate that with the described technique a good myocardial protection can be made. This procedure allows operating with a low risk in a completely arrested and relaxed heart for 130 minutes.
|Translated title of the contribution||Cardioplegia according to Bretschneider for valve replacement: clinical experiences and electronmicroscopical results|
|Number of pages||11|
|Journal||Thoracic and Cardiovascular Surgeon|
|State||Published - 1977|
ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine
- Cardiology and Cardiovascular Medicine