Cardiomyopathy Phenotypes and Outcomes for Children With Left Ventricular Myocardial Noncompaction: Results From the Pediatric Cardiomyopathy Registry

Pediatric Cardiomyopathy Registry Investigators

Research output: Contribution to journalArticle

53 Scopus citations

Abstract

Background Left ventricular noncompaction (LVNC) is a distinct form of cardiomyopathy characterized by hypertrabeculation of the left ventricle. The LVNC phenotype may occur in isolation or with other cardiomyopathy phenotypes. Prognosis is incompletely characterized in children. Methods and Results According to diagnoses from the National Heart, Lung, and Blood Institute-funded Pediatric Cardiomyopathy Registry from 1990 to 2008, 155 of 3,219 children (4.8%) had LVNC. Each LVNC patient was also classified as having an associated echocardiographically diagnosed cardiomyopathy phenotype: dilated (DCM), hypertrophic (HCM), restrictive (RCM), isolated, or indeterminate. The time to death or transplantation differed among the phenotypic groups (P =.035). Time to listing for cardiac transplantation significantly differed by phenotype (P

Original languageEnglish (US)
Pages (from-to)877-884
Number of pages8
JournalJournal of Cardiac Failure
Volume21
Issue number11
DOIs
StatePublished - Nov 1 2015

Keywords

  • Cardiomyopathy
  • heart failure
  • pediatrics

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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