Cardiac structure and function in fetuses of mothers infected with HIV: The prospective P2C2HIV multicenter study

L. K. Hornberger, Steven E Lipshultz, K. A. Easley, S. D. Colan, M. Schwartz, S. Kaplan, T. J. Starc, N. A. Ayres, W. W. Lai, D. S. Moodie, C. Kasten-Sportes, S. P. Sanders

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Background: This study was designed to determine if vertically transmitted HIV infection and maternal infection with HIV are associated with altered cardiovascular structure and function in utero. Methods: Fetal echocardiography was performed in 173 fetuses of 169 HIV-infected mothers (mean gestational age, 33.0 weeks; SD = 3.7 weeks) at 5 centers. Biparietal diameter, femur length, cardiovascular dimensions, and Doppler velocities through atrioventricular and semilunar valves and the umbilical artery were measured. Measurements were converted to z scores based on published normal data. Results: Fetuses determined after birth to be HIV-infected had similar echodardiographic findings as fetuses later determined to be HIV-uninfected except for slightly smaller left ventricular diastolic dimensions (P = .01). The femur length (P = .03) was also smaller in the fetuses postnatally identified as HIV-infected. Differences in cardiovascular dimensions and Doppler velocities were identified between fetuses of HIV-infected women and previously published normal fetal data. The reason for the differences may be a result of maternal HIV infection, maternal risk factors, or selection bias in the external control data. Conclusions: Vertically transmitted HIV infection may be associated with reduced left ventricular size but not with altered cardiac function in utero. Fetuses of HIV-infected mothers may have abnormal cardiovascular structure and function and increased placental vascular resistance, regardless of whether the fetuses are subsequently found to be infected with HIV.

Original languageEnglish
Pages (from-to)575-584
Number of pages10
JournalAmerican Heart Journal
Volume140
Issue number4
DOIs
StatePublished - Oct 19 2000
Externally publishedYes

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Multicenter Studies
Fetus
Mothers
HIV
HIV Infections
Femur
Umbilical Arteries
Selection Bias
Vascular Resistance
Gestational Age
Echocardiography
Parturition

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Hornberger, L. K., Lipshultz, S. E., Easley, K. A., Colan, S. D., Schwartz, M., Kaplan, S., ... Sanders, S. P. (2000). Cardiac structure and function in fetuses of mothers infected with HIV: The prospective P2C2HIV multicenter study. American Heart Journal, 140(4), 575-584. https://doi.org/10.1067/mhj.2000.109645

Cardiac structure and function in fetuses of mothers infected with HIV : The prospective P2C2HIV multicenter study. / Hornberger, L. K.; Lipshultz, Steven E; Easley, K. A.; Colan, S. D.; Schwartz, M.; Kaplan, S.; Starc, T. J.; Ayres, N. A.; Lai, W. W.; Moodie, D. S.; Kasten-Sportes, C.; Sanders, S. P.

In: American Heart Journal, Vol. 140, No. 4, 19.10.2000, p. 575-584.

Research output: Contribution to journalArticle

Hornberger, LK, Lipshultz, SE, Easley, KA, Colan, SD, Schwartz, M, Kaplan, S, Starc, TJ, Ayres, NA, Lai, WW, Moodie, DS, Kasten-Sportes, C & Sanders, SP 2000, 'Cardiac structure and function in fetuses of mothers infected with HIV: The prospective P2C2HIV multicenter study', American Heart Journal, vol. 140, no. 4, pp. 575-584. https://doi.org/10.1067/mhj.2000.109645
Hornberger, L. K. ; Lipshultz, Steven E ; Easley, K. A. ; Colan, S. D. ; Schwartz, M. ; Kaplan, S. ; Starc, T. J. ; Ayres, N. A. ; Lai, W. W. ; Moodie, D. S. ; Kasten-Sportes, C. ; Sanders, S. P. / Cardiac structure and function in fetuses of mothers infected with HIV : The prospective P2C2HIV multicenter study. In: American Heart Journal. 2000 ; Vol. 140, No. 4. pp. 575-584.
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AU - Kaplan, S.

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