Cardiac structure and function in fetuses of mothers infected with HIV: The prospective P2C2HIV multicenter study

L. K. Hornberger, S. E. Lipshultz, K. A. Easley, S. D. Colan, M. Schwartz, S. Kaplan, T. J. Starc, N. A. Ayres, W. W. Lai, D. S. Moodie, C. Kasten-Sportes, S. P. Sanders

Research output: Contribution to journalArticlepeer-review

37 Scopus citations


Background: This study was designed to determine if vertically transmitted HIV infection and maternal infection with HIV are associated with altered cardiovascular structure and function in utero. Methods: Fetal echocardiography was performed in 173 fetuses of 169 HIV-infected mothers (mean gestational age, 33.0 weeks; SD = 3.7 weeks) at 5 centers. Biparietal diameter, femur length, cardiovascular dimensions, and Doppler velocities through atrioventricular and semilunar valves and the umbilical artery were measured. Measurements were converted to z scores based on published normal data. Results: Fetuses determined after birth to be HIV-infected had similar echodardiographic findings as fetuses later determined to be HIV-uninfected except for slightly smaller left ventricular diastolic dimensions (P = .01). The femur length (P = .03) was also smaller in the fetuses postnatally identified as HIV-infected. Differences in cardiovascular dimensions and Doppler velocities were identified between fetuses of HIV-infected women and previously published normal fetal data. The reason for the differences may be a result of maternal HIV infection, maternal risk factors, or selection bias in the external control data. Conclusions: Vertically transmitted HIV infection may be associated with reduced left ventricular size but not with altered cardiac function in utero. Fetuses of HIV-infected mothers may have abnormal cardiovascular structure and function and increased placental vascular resistance, regardless of whether the fetuses are subsequently found to be infected with HIV.

Original languageEnglish (US)
Pages (from-to)575-584
Number of pages10
JournalAmerican Heart Journal
Issue number4
StatePublished - 2000
Externally publishedYes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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