Cardiac Scintigraphy With Technetium-99m-Labeled Bone-Seeking Tracers for Suspected Amyloidosis: JACC Review Topic of the Week

Mazen Hanna, Frederick L. Ruberg, Mathew S. Maurer, Angela Dispenzieri, Sharmila Dorbala, Rodney H. Falk, James Hoffman, Wael Jaber, Prem Soman, Ronald M. Witteles, Martha Grogan

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations

Abstract

Technetium-labeled cardiac scintigraphy (i.e., Tc-PYP scan) has been repurposed for the diagnosis of transthyretin amyloid cardiomyopathy (ATTR-CM). Validated in cohorts of patients with heart failure and echocardiographic and/or cardiac magnetic resonance imaging findings suggestive of cardiac amyloidosis, cardiac scintigraphy can confirm the diagnosis of ATTR-CM only when combined with blood and urine testing to exclude a monoclonal protein. Multisocietal guidelines support the nonbiopsy diagnosis of ATTR-CM using cardiac scintigraphy, yet emphasize its use in the appropriate clinical context and the crucial need to rule out light chain amyloid cardiomyopathy. Although increased awareness of ATTR-CM and the advent of effective therapy have led to rapid adoption of diagnostic scintigraphy, there is heterogeneity in adherence to consensus guidelines. This perspective outlines clinical scenarios wherein findings on technetium-labeled cardiac scintigraphy have been misinterpreted, reviews causes of false-negative and false-positive results, and provides strategies to avoid costly and potentially fatal misdiagnoses.

Original languageEnglish (US)
Pages (from-to)2851-2862
Number of pages12
JournalJournal of the American College of Cardiology
Volume75
Issue number22
DOIs
StatePublished - Jun 9 2020

Keywords

  • Tc-DPD
  • Tc-HMDP
  • Tc-PYP
  • amyloidosis
  • cardiomyopathy
  • diagnostic testing
  • Technetium-labeled bone scintigraphy
  • transthyretin

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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