Cardiac problems

Gul H. Dadlani, Steven E. Lipshultz

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Introduction As the survival of HIV-infected patients improves, the cardiovascular complications of HIV infection are becoming an increasingly common cause of morbidity and mortality. The prevalence of cardiovascular disease is estimated to be more than 90% in pediatric HIV patients [1–3]. The spectrum of cardiovascular disorders includes abnormalities in left ventricular performance, wall thickness, contractility, dilated cardiomyopathy, myocarditis, pericarditis, and rhythm disturbances. Cardiac complications have surpassed pulmonary disease as the leading cause of death in HIV-infected patients [4]. The recognition of cardiovascular complications can be very difficult because many patients are asymptomatic until late in the disease course. In addition, the cardiac symptoms can be inadvertently attributed to other causes such as pulmonary or infectious etiologies. Early detection of these symptoms is only possible if clinicians have a fundamental understanding of the wide array of cardiovascular complications associated with HIV infection. The initiation of routine screening and monitoring will allow clinicians the ability to intervene and hopefully prevent or delay the onset of these complications in the future. Risk factors Several risk factors for cardiovascular disease among HIV-infected children have been described. The triad of encephalopathy, wasting, and low CD4 counts in children with HIV have been shown to be associated with an increased the risk of cardiovascular complications and decreased survival [5]. Encephalopathy can lead to an autonomic neuropathy, which may precipitate arrhythmias or even sudden death [5].

Original languageEnglish (US)
Title of host publicationHandbook of Pediatric HIV Care, Second Edition
PublisherCambridge University Press
Pages554-566
Number of pages13
ISBN (Electronic)9780511544781
ISBN (Print)0521529069, 9780521529068
DOIs
StatePublished - Jan 1 2006

ASJC Scopus subject areas

  • Medicine(all)

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    Dadlani, G. H., & Lipshultz, S. E. (2006). Cardiac problems. In Handbook of Pediatric HIV Care, Second Edition (pp. 554-566). Cambridge University Press. https://doi.org/10.1017/CBO9780511544781.025