Cardiac performance, biomarkers and gene expression studies in previously sedentary men participating in half-marathon training

Danica D. Vance, Gordon L. Chen, Mark Stoutenberg, Robert J. Myerburg, Kevin Jacobs, Lubov Nathanson, Arlette Perry, David Seo, Pascal J. Goldschmidt-Clermont, Evadnie Rampersaud

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Background: The mechanisms through which exercise reduces cardiovascular disease are not fully understood. We used echocardiograms, cardiac biomarkers and gene expression to investigate cardiovascular effects associated with exercise training. Methods: Nineteen sedentary men (22-37 years) completed a 17-week half-marathon training program. Serial measurements of resting heart rate, blood pressure, maximum oxygen consumption, lipids, C-reactive protein, cardiac troponin T, echocardiograms and blood for gene expression were obtained from baseline to peak training. Controls included 22 sedentary men who did not exercise. Results: Among the training group, VO2 max increased from 37.1 to 42.0ml/kg/min (p < 0.001). Significant changes were seen in left ventricular wall thickness and mass, stroke volume, resting heart rate and blood pressure (p < 0.001). The control group demonstrated no significant changes. Expression profiling in the training group identified 10 significantly over-expressed and 53 significantly under-expressed loci involved in inflammatory pathways. Dividing the training group into high and low responders based on percent change in VO2 max identified loci that differentiated these two groups at baseline and after training. Conclusion: Intensive exercise training leads to significant increase in cardiac and hemodynamic performance, and significant changes in expression of genes involved in immune and inflammatory response.

Original languageEnglish (US)
Article number6
JournalBMC Sports Science, Medicine and Rehabilitation
Issue number1
StatePublished - Feb 19 2014


  • Cardiovascular
  • Exercise
  • Gene expression
  • Response

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation
  • Rehabilitation


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