Cardiac myxoma: Review and update of contemporary immunohistochemical markers and molecular pathology

Jaylou M. Velez Torres, Ernesto Martinez Duarte, Julio A. Diaz-Perez, Andrew E. Rosenberg

Research output: Contribution to journalReview articlepeer-review

Abstract

Cardiac myxoma is an uncommon benign mesenchymal neoplasm of the heart. It usually arises in the left atrium, near the valve of the fossa ovalis, and most frequently affects adults in the third through the sixth decades of life. It is hypothesized to arise from subendothelial vasoformative reserve cells or primitive cells that differentiate along the lines of the endothelium, but this remains speculative. Microscopically, the neoplastic cells are arranged individually, and nests, and are oriented in single or multiple layers around vascular channels. The neoplastic cells are immunoreactive for vimentin, calretinin, S100, nonspecific enolase, factor VIII, CD31, and CD34. The tumor can have diverse clinical presentations depending on its location and extent of disease and is predisposed to embolization. The current treatment is prompt surgical excision.

Original languageEnglish (US)
Pages (from-to)380-384
Number of pages5
JournalAdvances in anatomic pathology
Volume27
Issue number6
DOIs
StatePublished - Nov 1 2020

Keywords

  • benign cardiac tumors
  • cardiac myxoma
  • cardiac neoplasms
  • embolization
  • metastasis

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine

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