Cardiac myxoma (Endocardioma). An immunocytochemical assessment of histogenesis

Azorides R. Morales; Gerald Fine; Albert Castro; Mehrdad Nadji

doi:10.1016/S0046-8177(81)80194-3

Cardiac myxoma (Endocardioma). An immunocytochemical assessment of histogenesis

Azorides R. Morales, Gerald Fine, Albert Castro, Mehrdad Nadji

Pathology

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

Abstract

Eighteen cardiac myoxomas having a variety of histologic patterns were stained for factor VIII related antigen utilizing the peroxidase-antiperoxidase technique. Regardless of their histologic appearance, intense reactivity for factor VIII related antigen was found in tumor cells, whereas four other intracardiac tumors did not stain. Since factor VIII related antigen is known to be elaborated only by endothelial cells and megakaryocytes, it is concluded that cardiac myxoma cells, which similarly synthesize this antigen, originate from endothelial or endocardial cells.

Original language	English (US)
Pages (from-to)	896-899
Number of pages	4
Journal	Human pathology
Volume	12
Issue number	10
DOIs	https://doi.org/10.1016/S0046-8177(81)80194-3
State	Published - Oct 1981

ASJC Scopus subject areas

Pathology and Forensic Medicine

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10.1016/S0046-8177(81)80194-3

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abstract = "Eighteen cardiac myoxomas having a variety of histologic patterns were stained for factor VIII related antigen utilizing the peroxidase-antiperoxidase technique. Regardless of their histologic appearance, intense reactivity for factor VIII related antigen was found in tumor cells, whereas four other intracardiac tumors did not stain. Since factor VIII related antigen is known to be elaborated only by endothelial cells and megakaryocytes, it is concluded that cardiac myxoma cells, which similarly synthesize this antigen, originate from endothelial or endocardial cells.",

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AU - Castro, Albert

AU - Nadji, Mehrdad

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AB - Eighteen cardiac myoxomas having a variety of histologic patterns were stained for factor VIII related antigen utilizing the peroxidase-antiperoxidase technique. Regardless of their histologic appearance, intense reactivity for factor VIII related antigen was found in tumor cells, whereas four other intracardiac tumors did not stain. Since factor VIII related antigen is known to be elaborated only by endothelial cells and megakaryocytes, it is concluded that cardiac myxoma cells, which similarly synthesize this antigen, originate from endothelial or endocardial cells.

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Cardiac myxoma (Endocardioma). An immunocytochemical assessment of histogenesis

Abstract

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