Abstract
Alterations in repolarization following prolonged peri-ods of ventricular pacing, termed "cardiac memory, " have been well documented. Postpacing changes in cardiac function have also been noted in hypertrophie cardiomyopathy. This study was designed to evaluate the effects of ventricular pacing on postpacing diastolic function and its relationship to repolarization changes. Eight subjects (mean age, 76 yr) with permanent pacemakers were enrolled in this study. Each subject was evaluated at a fixed pacing rate with recording of electrocardiographic and echocardiographic data. Seven sets of measurements were performed in the same sequential pattern: 1) after 1 wk of atrial pacing, 2) within 10 min after initiation of atrioventricular sequential pacing (ventricular pacing), 3) within 10 min after termination of l h of ventricular pacing, 4) after 1 wk of ventricular pacing, and 5) within 10 min, at 1 h, and at 24 h after termination of ventricular pacing. All subjects had repolarization changes characteristic of cardiac memory only after 1 wk of ventricular pacing. Changes in repolarization parameters were accompanied by changes in peak left ventricular filling rate (dD/dt/D; P = 0.02) and isovolumic relaxation time (IVKT; P = 0.03) that at 24 h approached baseline values. Correlations existed between changes in the Q-T interval and IVRT (r = 0.53, P = 0.007) and between changes in T wave amplitude and dD/dt/D (r = 0.48, P = 0.018) after long-term ventricular pacing. Thus changes in both repolarization and diastolic function persist after cessation of ventricular pacing and lend support to the concept of electrical and mechanical cardiac memory.
| Original language | English (US) |
|---|---|
| Journal | American Journal of Physiology |
| Volume | 272 |
| Issue number | 4 PART 2 |
| State | Published - Dec 1 1997 |
| Externally published | Yes |
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Keywords
- Isovolumic relaxation time
- Left ventricular filling
- Pacemaker
- Q-T interval
- T wave
ASJC Scopus subject areas
- Physiology (medical)
Cite this
Cardiac memory : A mechanical and electrical phenomenon. / Alessandrini, Renato S.; McPherson, David D.; Kadish, Alan H.; Kane, Bonnie J.; Goldberger, Jeffrey.
In: American Journal of Physiology, Vol. 272, No. 4 PART 2, 01.12.1997.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cardiac memory
T2 - A mechanical and electrical phenomenon
AU - Alessandrini, Renato S.
AU - McPherson, David D.
AU - Kadish, Alan H.
AU - Kane, Bonnie J.
AU - Goldberger, Jeffrey
PY - 1997/12/1
Y1 - 1997/12/1
N2 - Alterations in repolarization following prolonged peri-ods of ventricular pacing, termed "cardiac memory, " have been well documented. Postpacing changes in cardiac function have also been noted in hypertrophie cardiomyopathy. This study was designed to evaluate the effects of ventricular pacing on postpacing diastolic function and its relationship to repolarization changes. Eight subjects (mean age, 76 yr) with permanent pacemakers were enrolled in this study. Each subject was evaluated at a fixed pacing rate with recording of electrocardiographic and echocardiographic data. Seven sets of measurements were performed in the same sequential pattern: 1) after 1 wk of atrial pacing, 2) within 10 min after initiation of atrioventricular sequential pacing (ventricular pacing), 3) within 10 min after termination of l h of ventricular pacing, 4) after 1 wk of ventricular pacing, and 5) within 10 min, at 1 h, and at 24 h after termination of ventricular pacing. All subjects had repolarization changes characteristic of cardiac memory only after 1 wk of ventricular pacing. Changes in repolarization parameters were accompanied by changes in peak left ventricular filling rate (dD/dt/D; P = 0.02) and isovolumic relaxation time (IVKT; P = 0.03) that at 24 h approached baseline values. Correlations existed between changes in the Q-T interval and IVRT (r = 0.53, P = 0.007) and between changes in T wave amplitude and dD/dt/D (r = 0.48, P = 0.018) after long-term ventricular pacing. Thus changes in both repolarization and diastolic function persist after cessation of ventricular pacing and lend support to the concept of electrical and mechanical cardiac memory.
AB - Alterations in repolarization following prolonged peri-ods of ventricular pacing, termed "cardiac memory, " have been well documented. Postpacing changes in cardiac function have also been noted in hypertrophie cardiomyopathy. This study was designed to evaluate the effects of ventricular pacing on postpacing diastolic function and its relationship to repolarization changes. Eight subjects (mean age, 76 yr) with permanent pacemakers were enrolled in this study. Each subject was evaluated at a fixed pacing rate with recording of electrocardiographic and echocardiographic data. Seven sets of measurements were performed in the same sequential pattern: 1) after 1 wk of atrial pacing, 2) within 10 min after initiation of atrioventricular sequential pacing (ventricular pacing), 3) within 10 min after termination of l h of ventricular pacing, 4) after 1 wk of ventricular pacing, and 5) within 10 min, at 1 h, and at 24 h after termination of ventricular pacing. All subjects had repolarization changes characteristic of cardiac memory only after 1 wk of ventricular pacing. Changes in repolarization parameters were accompanied by changes in peak left ventricular filling rate (dD/dt/D; P = 0.02) and isovolumic relaxation time (IVKT; P = 0.03) that at 24 h approached baseline values. Correlations existed between changes in the Q-T interval and IVRT (r = 0.53, P = 0.007) and between changes in T wave amplitude and dD/dt/D (r = 0.48, P = 0.018) after long-term ventricular pacing. Thus changes in both repolarization and diastolic function persist after cessation of ventricular pacing and lend support to the concept of electrical and mechanical cardiac memory.
KW - Isovolumic relaxation time
KW - Left ventricular filling
KW - Pacemaker
KW - Q-T interval
KW - T wave
UR - http://www.scopus.com/inward/record.url?scp=33745359350&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33745359350&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:33745359350
VL - 272
JO - American Journal of Physiology - Cell Physiology
JF - American Journal of Physiology - Cell Physiology
SN - 0363-6143
IS - 4 PART 2
ER -