TY - JOUR
T1 - Cardiac function in fetuses and newborns exposed to low-dose aspirin during pregnancy
AU - Di Sessa, Thomas G.
AU - Moretti, Michael L.
AU - Khoury, Aldo
AU - Pulliam, Derrick A.
AU - Arheart, Kristopher L.
AU - Sibai, Baha M.
PY - 1994
Y1 - 1994
N2 - Objective: Our purpose was to evaluate cardiac function in fetuses exposed to low-dose aspirin. Study Design: To assess its efficacy in preventing preeclampsia, 60 mg/day aspirin or a matching placebo was administered to women in a double-blind fashion during the second and third trimesters. As a part of this study, 146 echo Doppler studies were performed on 63 fetuses from 15 to 40 weeks' gestation. These studies allowed assessment of systolic and diastolic cardiac function. Cardiac function was also assessed in 87 neonates. Results: Throughout gestation ductus arteriosus flow velocity, right ventricular output and diastolic area, and left ventricular output and diastolic area all increased and were similar in both aspirin- and placebo-exposed fetuses. Fetal diastolic flow velocities were also alike in both groups. The two groups had similar gestational ages at delivery (39.2 ± 2.3 vs 38.7 ± 2.7 weeks) and birth weights (3174 ± 575 vs 3105 ± 579 gm, respectively). Furthermore, there was no difference in fractional shortening, cardiac output, prevalence of tricuspid regurgitation, or patency of the ductus arteriosus at birth between the two groups. Conclusion: The circulation of fetuses and newborns is not affected adversely by exposure to low-dose aspirin during gestation.
AB - Objective: Our purpose was to evaluate cardiac function in fetuses exposed to low-dose aspirin. Study Design: To assess its efficacy in preventing preeclampsia, 60 mg/day aspirin or a matching placebo was administered to women in a double-blind fashion during the second and third trimesters. As a part of this study, 146 echo Doppler studies were performed on 63 fetuses from 15 to 40 weeks' gestation. These studies allowed assessment of systolic and diastolic cardiac function. Cardiac function was also assessed in 87 neonates. Results: Throughout gestation ductus arteriosus flow velocity, right ventricular output and diastolic area, and left ventricular output and diastolic area all increased and were similar in both aspirin- and placebo-exposed fetuses. Fetal diastolic flow velocities were also alike in both groups. The two groups had similar gestational ages at delivery (39.2 ± 2.3 vs 38.7 ± 2.7 weeks) and birth weights (3174 ± 575 vs 3105 ± 579 gm, respectively). Furthermore, there was no difference in fractional shortening, cardiac output, prevalence of tricuspid regurgitation, or patency of the ductus arteriosus at birth between the two groups. Conclusion: The circulation of fetuses and newborns is not affected adversely by exposure to low-dose aspirin during gestation.
KW - Fetal cardiovascular hemodynamics
KW - fetal echocardiography
KW - medications in pregnancy
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U2 - 10.1016/S0002-9378(94)70056-7
DO - 10.1016/S0002-9378(94)70056-7
M3 - Article
C2 - 7943099
AN - SCOPUS:0028027559
VL - 171
SP - 892
EP - 900
JO - American Journal of Obstetrics and Gynecology
JF - American Journal of Obstetrics and Gynecology
SN - 0002-9378
IS - 4
ER -