Cardiac biomarkers - The old and the new: A review

Vikas Singh, Pedro Martinezclark, Mario Pascual, Eric Scot Shaw, William W. O'Neill

Research output: Contribution to journalArticle

36 Citations (Scopus)


Biomarkers are biological parameters that can be objectively measured and quantified as indicators of normal biologic processes, pathogenic processes, or responses to a therapeutic intervention. Typically thought of as disease process screening, diagnosing, or monitoring tools, biomarkers may also be used to determine disease susceptibility and eligibility for specific therapies. Cardiac biomarkers are protein components of cell structures that are released into circulation when myocardial injury occurs. They play a pivotal role in the diagnosis, risk stratification, and treatment of patients with chest pain and suspected acute coronary syndrome and those with acute exacerbations of heart failure. Cardiac markers are central to the new definition of acute myocardial infarction put forward by the American College of Cardiology and the European Society of Cardiology. Active investigation has brought forward an increasingly large number of novel candidate markers but few have withstood the test of time and become integrated into contemporary clinical care because of their readily apparent diagnostic, prognostic, or therapeutic utility.

Original languageEnglish
Pages (from-to)244-256
Number of pages13
JournalCoronary Artery Disease
Issue number4
StatePublished - Jun 1 2010


Disease Susceptibility
Cellular Structures
Acute Coronary Syndrome
Chest Pain
Heart Failure
Myocardial Infarction
Wounds and Injuries


  • Acute
  • Coronary
  • Novel
  • Protein
  • Syndrome

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Singh, V., Martinezclark, P., Pascual, M., Shaw, E. S., & O'Neill, W. W. (2010). Cardiac biomarkers - The old and the new: A review. Coronary Artery Disease, 21(4), 244-256.

Cardiac biomarkers - The old and the new : A review. / Singh, Vikas; Martinezclark, Pedro; Pascual, Mario; Shaw, Eric Scot; O'Neill, William W.

In: Coronary Artery Disease, Vol. 21, No. 4, 01.06.2010, p. 244-256.

Research output: Contribution to journalArticle

Singh, V, Martinezclark, P, Pascual, M, Shaw, ES & O'Neill, WW 2010, 'Cardiac biomarkers - The old and the new: A review', Coronary Artery Disease, vol. 21, no. 4, pp. 244-256.
Singh V, Martinezclark P, Pascual M, Shaw ES, O'Neill WW. Cardiac biomarkers - The old and the new: A review. Coronary Artery Disease. 2010 Jun 1;21(4):244-256.
Singh, Vikas ; Martinezclark, Pedro ; Pascual, Mario ; Shaw, Eric Scot ; O'Neill, William W. / Cardiac biomarkers - The old and the new : A review. In: Coronary Artery Disease. 2010 ; Vol. 21, No. 4. pp. 244-256.
title = "Cardiac biomarkers - The old and the new: A review",
abstract = "Lippincott Williams & Wilkins.",
keywords = "Acute, Coronary, Novel, Protein, Syndrome",
author = "Vikas Singh and Pedro Martinezclark and Mario Pascual and Shaw, {Eric Scot} and O'Neill, {William W.}",
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