Cardiac, Aortic, and Pulmonary Arteriopathy in HIV-Infected Children: The Prospective p2C2 HIV Multicenter Study

Antonio R. Perez-Atayde, D. I. Kearney, J. T. Bricker, S. D. Colan, K. A. Easley, S. Kaplan, W. W. Lai, S. E. Lipshultz, D. S. Moodie, G. Sopko, T. J. Starc

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations


Arteriopathy in human immunodeficiency virus (HIV)-infected patients is being increasingly recognized, especially in children. However, few studies have histologically evaluated the coronary arteries in HIV-infected children, and none have systematically assessed the aorta and pulmonary arteries. The coronary arteries, thoracic aorta, and the main and branch pulmonary arteries from the postmortem hearts of 14 HIV-infected children were systematically reviewed for vasculopathic lesions and compared with 14 age-matched controls. Findings from the HIV-infected children were compared with clinical, laboratory, and other postmortem findings. Coronary arteriopathy, seen in seven (50%) of the HIV-infected children, was primarily calcific, and it was associated with decreased CD3 and CD4 peripheral blood counts. Large vessel arteriopathy, seen in 9 (64%) of the 14 HIV-infected children, was primarily centered on the vasa vasorum and consisted mainly of medial hypertrophy and chronic inflammation. Large vessel lesions were associated with increased left ventricular mass z-scores (P = 0.02), and 78% of patients with large vessel arteriopathy had postmortem cardiomegaly. Coronary and large vessel arteriopathies are common in pediatric HIV-infection and have different clinicopathologic features suggesting different pathogenesis.

Original languageEnglish (US)
Pages (from-to)61-70
Number of pages10
JournalPediatric and Developmental Pathology
Issue number1
StatePublished - 2004


  • Arteriosclerosis
  • Cardiomyopathy
  • Vasa vasorum

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pathology and Forensic Medicine


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