Cardiac and inflammatory biomarkers in perinatally HIV-infected and HIV-exposed uninfected children

James D. Wilkinson, Paige L. Williams, Wendy Yu, Steven D. Colan, Armando J Mendez, Justin P.V. Zachariah, Russell B. Van Dyke, William T. Shearer, Renee E. Margossian, Steven E Lipshultz

Research output: Contribution to journalArticle

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Abstract

Objectives: To compare distributions of serum cardiac and inflammatory biomarkers between perinatally HIV-infected (PHIV) and perinatally HIV-exposed uninfected (PHEU) children, to evaluate their associations with echocardiographic measures, and among PHIV youth, with antiretroviral therapy (ART) and HIV disease severity measures. Design: Cross-sectional analysis of temporally paired serum samples for biomarkers and echocardiograms in a prospective multicenter cohort study of PHIV and PHEU youth. Methods: Serum samples were analyzed among 402 youth in the PHACS Adolescent Master Protocol (AMP) for high-sensitivity cardiac troponin-T (hs-cTnT, a cardiomyocyte injury marker), N-Terminal-pro-brain natriuretic peptide (NT-proBNP, a myocardial stress marker), and inflammatory markers [high-sensitivity C-reactive protein, interleukin (IL)-1, IL-6, IL-8, IL-10, IL-18, tumor necrosis factor-α (TNF-α), and soluble TNF receptor II (sTNF-RII)]. Echocardiograms were centrally measured and parameters converted to z cores to account for differences in age and body size. Results: Compared with PHEU (N = 156), PHIV youth (N = 246) more often had detectable hs-cTnT and higher levels of sTNF-RII and IL-18. Higher inflammatory biomarkers were generally associated with higher left ventricular (LV) wall stress and lower LV function and LV mass in the two groups. Among PHIV youth, the biomarkers were more strongly associated with current rather than historical immunologic and virologic status. Conclusion: PHEU and PHIV have modest, significant differences in serum levels of specific inflammatory and active myocardial injury biomarkers. Higher biomarker levels were associated with lower LV mass and shifts in LV structure. Further study is warranted on the longitudinal role of cardiac and inflammatory biomarkers for targeting interventions among PHIV and PHEU youth.

Original languageEnglish (US)
Pages (from-to)1267-1277
Number of pages11
JournalAIDS
Volume32
Issue number10
DOIs
StatePublished - Jun 19 2018

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Biomarkers
HIV
Interleukin-18
Tumor Necrosis Factor Receptors
Serum
Troponin T
Brain Natriuretic Peptide
Wounds and Injuries
Body Size
Interleukin-8
Interleukin-1
Left Ventricular Function
Cardiac Myocytes
Interleukin-10
C-Reactive Protein
Multicenter Studies
Interleukin-6
Cohort Studies
Tumor Necrosis Factor-alpha
Cross-Sectional Studies

Keywords

  • antiretroviral therapy
  • biomarkers
  • echocardiography
  • HIV
  • pediatric

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

Cite this

Wilkinson, J. D., Williams, P. L., Yu, W., Colan, S. D., Mendez, A. J., Zachariah, J. P. V., ... Lipshultz, S. E. (2018). Cardiac and inflammatory biomarkers in perinatally HIV-infected and HIV-exposed uninfected children. AIDS, 32(10), 1267-1277. https://doi.org/10.1097/QAD.0000000000001810

Cardiac and inflammatory biomarkers in perinatally HIV-infected and HIV-exposed uninfected children. / Wilkinson, James D.; Williams, Paige L.; Yu, Wendy; Colan, Steven D.; Mendez, Armando J; Zachariah, Justin P.V.; Van Dyke, Russell B.; Shearer, William T.; Margossian, Renee E.; Lipshultz, Steven E.

In: AIDS, Vol. 32, No. 10, 19.06.2018, p. 1267-1277.

Research output: Contribution to journalArticle

Wilkinson, JD, Williams, PL, Yu, W, Colan, SD, Mendez, AJ, Zachariah, JPV, Van Dyke, RB, Shearer, WT, Margossian, RE & Lipshultz, SE 2018, 'Cardiac and inflammatory biomarkers in perinatally HIV-infected and HIV-exposed uninfected children', AIDS, vol. 32, no. 10, pp. 1267-1277. https://doi.org/10.1097/QAD.0000000000001810
Wilkinson, James D. ; Williams, Paige L. ; Yu, Wendy ; Colan, Steven D. ; Mendez, Armando J ; Zachariah, Justin P.V. ; Van Dyke, Russell B. ; Shearer, William T. ; Margossian, Renee E. ; Lipshultz, Steven E. / Cardiac and inflammatory biomarkers in perinatally HIV-infected and HIV-exposed uninfected children. In: AIDS. 2018 ; Vol. 32, No. 10. pp. 1267-1277.
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abstract = "Objectives: To compare distributions of serum cardiac and inflammatory biomarkers between perinatally HIV-infected (PHIV) and perinatally HIV-exposed uninfected (PHEU) children, to evaluate their associations with echocardiographic measures, and among PHIV youth, with antiretroviral therapy (ART) and HIV disease severity measures. Design: Cross-sectional analysis of temporally paired serum samples for biomarkers and echocardiograms in a prospective multicenter cohort study of PHIV and PHEU youth. Methods: Serum samples were analyzed among 402 youth in the PHACS Adolescent Master Protocol (AMP) for high-sensitivity cardiac troponin-T (hs-cTnT, a cardiomyocyte injury marker), N-Terminal-pro-brain natriuretic peptide (NT-proBNP, a myocardial stress marker), and inflammatory markers [high-sensitivity C-reactive protein, interleukin (IL)-1, IL-6, IL-8, IL-10, IL-18, tumor necrosis factor-α (TNF-α), and soluble TNF receptor II (sTNF-RII)]. Echocardiograms were centrally measured and parameters converted to z cores to account for differences in age and body size. Results: Compared with PHEU (N = 156), PHIV youth (N = 246) more often had detectable hs-cTnT and higher levels of sTNF-RII and IL-18. Higher inflammatory biomarkers were generally associated with higher left ventricular (LV) wall stress and lower LV function and LV mass in the two groups. Among PHIV youth, the biomarkers were more strongly associated with current rather than historical immunologic and virologic status. Conclusion: PHEU and PHIV have modest, significant differences in serum levels of specific inflammatory and active myocardial injury biomarkers. Higher biomarker levels were associated with lower LV mass and shifts in LV structure. Further study is warranted on the longitudinal role of cardiac and inflammatory biomarkers for targeting interventions among PHIV and PHEU youth.",
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AU - Wilkinson, James D.

AU - Williams, Paige L.

AU - Yu, Wendy

AU - Colan, Steven D.

AU - Mendez, Armando J

AU - Zachariah, Justin P.V.

AU - Van Dyke, Russell B.

AU - Shearer, William T.

AU - Margossian, Renee E.

AU - Lipshultz, Steven E

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N2 - Objectives: To compare distributions of serum cardiac and inflammatory biomarkers between perinatally HIV-infected (PHIV) and perinatally HIV-exposed uninfected (PHEU) children, to evaluate their associations with echocardiographic measures, and among PHIV youth, with antiretroviral therapy (ART) and HIV disease severity measures. Design: Cross-sectional analysis of temporally paired serum samples for biomarkers and echocardiograms in a prospective multicenter cohort study of PHIV and PHEU youth. Methods: Serum samples were analyzed among 402 youth in the PHACS Adolescent Master Protocol (AMP) for high-sensitivity cardiac troponin-T (hs-cTnT, a cardiomyocyte injury marker), N-Terminal-pro-brain natriuretic peptide (NT-proBNP, a myocardial stress marker), and inflammatory markers [high-sensitivity C-reactive protein, interleukin (IL)-1, IL-6, IL-8, IL-10, IL-18, tumor necrosis factor-α (TNF-α), and soluble TNF receptor II (sTNF-RII)]. Echocardiograms were centrally measured and parameters converted to z cores to account for differences in age and body size. Results: Compared with PHEU (N = 156), PHIV youth (N = 246) more often had detectable hs-cTnT and higher levels of sTNF-RII and IL-18. Higher inflammatory biomarkers were generally associated with higher left ventricular (LV) wall stress and lower LV function and LV mass in the two groups. Among PHIV youth, the biomarkers were more strongly associated with current rather than historical immunologic and virologic status. Conclusion: PHEU and PHIV have modest, significant differences in serum levels of specific inflammatory and active myocardial injury biomarkers. Higher biomarker levels were associated with lower LV mass and shifts in LV structure. Further study is warranted on the longitudinal role of cardiac and inflammatory biomarkers for targeting interventions among PHIV and PHEU youth.

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