Carcinomas with trophoblastic differentiation and secretion of chorionic gonadotrophins

Francisco Civantos, Arkadi M. Rywlin

Research output: Contribution to journalArticlepeer-review

84 Scopus citations


Three postmenopausal women with ovarian carcinomas, a mucinous cystadenocarcinoma, and two papillary adenocarcinomas showed foci of poorly differentiated tumor with numerous giant cells. Similar histologic features were seen in a carcinoma of the uterus in an 87‐year‐old woman and a papillary transitional cell carcinoma of the bladder in a man. All 5 cases had urinary chorionic gonadotrophin activity ranging from 1,000 to 25,000 I. U. Immunofluorescent staining showed the presence of chorionic gonadotrophin in the tumor giant cells in all 5 patients. The basic lesion in all 5 cases was a carcinoma with areas of trophoblastic differentiation. The literature of ovarian choriocarcinomas and of carcinomas with chorionic gonadotrophin activity is reviewed.

Original languageEnglish (US)
Pages (from-to)789-798
Number of pages10
Issue number3
StatePublished - Mar 1972
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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