Carcinomas of Bartholin's gland: Histogenesis and the etiological role of human papillomavirus

Juan C. Felix, Richard J Cote, Elmer E W Kramer, Patricia Saigo, Gary H. Goldman

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Abstract

In this study, we examine 10 primary carcinomas of Bartholin's gland, including seven squamous carcinomas, two adenoid cystic carcinomas, and one adenocarcinoma, as well as four non-neoplastic Bartholin's gland. Six of seven squamous cell carcinomas contained human papillomavirus (HPV) type 16 DNA detectable by the polymerase chain reaction; one of these demonstrated HPV type 16 by in situ hybridization. The two adenoid cystic carcinomas, the adenocarcinoma, and the non-neoplastic Bartholin's gland epithelium showed no evidence of HPV DNA by polymerase chain reaction or in situ hybridization. A panel of eight antibodies (Cam 5.2, B72.3, CEA, EMA, MCA, Lewis X, ER, and PR) demonstrate that the squamous, transition zone, duct, acinar, and myoepithelial cells of Bartholin's gland are antigenically distinct, and are similar to those reported in analogous areas of the uterine cervix. Squamous carcinoma and adenocarcinomas of Bartholin's gland are antigenically similar, and seem to arise from the transition zone of the Bartholin's gland duct. The origin of adenoid cystic carcinomas is more difficult to determine; it is distinct from squamous and adenocarcinomas and seems more likely to arise from myoepithelial cells. We conclude that adenocarcinoma and squamous cell carcinoma of Bartholin's gland arise in the transition zone of Bartholin's gland, which is similar to the transition zone of the uterine cervix. We also show that HPV is associated with Bartholin's gland carcinoma and may play a role in the genesis of malignancy.

Original languageEnglish
Pages (from-to)925-933
Number of pages9
JournalAmerican Journal of Pathology
Volume142
Issue number3
StatePublished - Mar 1 1993
Externally publishedYes

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Bartholin's Glands
Carcinoma
Adenocarcinoma
Adenoid Cystic Carcinoma
Squamous Cell Carcinoma
Human papillomavirus 16
DNA-Directed DNA Polymerase
Cervix Uteri
In Situ Hybridization
Polymerase Chain Reaction
Acinar Cells
Epithelium

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Carcinomas of Bartholin's gland : Histogenesis and the etiological role of human papillomavirus. / Felix, Juan C.; Cote, Richard J; Kramer, Elmer E W; Saigo, Patricia; Goldman, Gary H.

In: American Journal of Pathology, Vol. 142, No. 3, 01.03.1993, p. 925-933.

Research output: Contribution to journalArticle

Felix, Juan C. ; Cote, Richard J ; Kramer, Elmer E W ; Saigo, Patricia ; Goldman, Gary H. / Carcinomas of Bartholin's gland : Histogenesis and the etiological role of human papillomavirus. In: American Journal of Pathology. 1993 ; Vol. 142, No. 3. pp. 925-933.
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