Carcinoembryonic antigen gene family: Molecular cloning of cDNA for a PSβG FL-NCA glycoprotein with a novel domain arrangement

Wasif Noor Khan, Sten Hammarström

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

Human fetal liver contains a family of carcinoembryonic antigen related glycoproteins called the pregnancy specific β1 glycoprotein/fetal liver non specific cross-reactive antigen ( PSβG FL-NCA) glycoprotein family. The sequence for the major FL-NCA species has been reported [Khan et al., Proc. Natl. Acad. Sci. USA 1989, 86 in press]. Two additional CEA-related fetal liver glycoproteins FL-NCA-2 and 3 were cloned, sequenced and expressed. FL-NCA-3 is a new gene family member. It has a unique domain arrangement (N-A2-B2-T) and contains a hydrophobic tail. FL-NCA-3 has a molecular weight of 54 kD and is released from the transfected cells. Like three other members of the family, FL-NCA-3 contains the Arg-Gly-Asp sequence in a position in the N-domain corresponding to complementarity determining region 3 of immunoglobulin. FL-NCA-2 is identical in structure to PSβG-D previously found in placenta. The PSβG FL-NCA glycoprotein family may be involved in processes related to cell adhesion and cell differentiation.

Original languageEnglish (US)
Pages (from-to)525-535
Number of pages11
JournalBiochemical and biophysical research communications
Volume161
Issue number2
DOIs
StatePublished - Jun 15 1989
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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