Carcinoembryonic antigen gene family members in submandibular salivary gland: Demonstration of pregnancy-specific glycoproteins by cDNA cloning

Fairouz Zoubir, Wasif Noor Khan, Sten Hammarström

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

We have recently shown that human submandibular salivary gland and saliva contain a number of glycoproteins belonging to the carcinoembryonic antigen (CEA) gene family. The members of the CEA family can be divided into the CEA subgroup and the pregnancy specific β1 glycoprotein (PSG) subgroup. The latter glycoproteins are abundant in placenta and fetal liver. Here we report that PSG's are expressed in normal adult submandibular salivary gland. Thus, cDNA cloning and sequencing gave two clones (SG5 and SG9) which coded for glycoproteins with a domain arrangement of N-A1-A2-B2-C and a third clone (SG8) which coded for a glycoprotein with a domain arrangement of N-A1-B2-C. SG5 is identical to PSG3, and SG9 to PSGld, while SG8 most probably corresponds to PSG2. The 3′ untranslated regions of the different members of the PSG subgroup contain highly homologous segments, suggesting a common evolutionary origin.

Original languageEnglish (US)
Pages (from-to)203-216
Number of pages14
JournalBiochemical and biophysical research communications
Volume169
Issue number1
DOIs
StatePublished - May 31 1990
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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