Carbon nanotube aqueous sol-gel composites: Enzyme-friendly platforms for the development of stable biosensors

Vasilis G. Gavalas, Stacy A. Law, J. Christopher Ball, Rodney Andrews, Leonidas G. Bachas

Research output: Contribution to journalArticle

108 Scopus citations

Abstract

A new type of composite material based on carbon nanotubes and an aqueous sol-gel process has been developed. The electrochemical characteristics of these composites were investigated and compared to composites made with an alkoxy silane sol-gel process. The use of carbon nanotubes, as the conductive part of the composite, facilitated fast electron transfer rates. The feasibility of this type of composite for the development of biosensors was demonstrated using L-amino acid oxidase. The stability of the enzyme was increased when it was encapsulated in the aqueous sol-gel, and the sensor retained more that 50% of its response after 1 month of testing.

Original languageEnglish (US)
Pages (from-to)247-252
Number of pages6
JournalAnalytical Biochemistry
Volume329
Issue number2
DOIs
StatePublished - Jun 15 2004

Keywords

  • Aqueous sol-gels
  • Biosensor
  • Carbon nanotubes
  • Composite electrodes
  • Enzyme stability

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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