Carbon monoxide intoxication: Clinical features, neuropathology and mechanisms of injury

Research output: Contribution to journalArticle

81 Citations (Scopus)

Abstract

CO intoxication, by producing cerebral hypoxia-ischaemia, may trigger neuropathological events which result in delayed neurological relapse even in patients whose earlier clinical course has appeared deceptively benign. The physician's index of suspicion must therefore be high, and it should be remembered that, even in major CO exposures, blood COHb levels may be low if a period of several hours has elapsed since exposure. The importance of recognising occult CO exposure (28) and of treating symptomatic patients promptly (29,30) cannot be overemphasised. Immediate administration of high concentrations of inspired oxygen (including hyperbaric oxygenation, if available) is the primary therapy. Hypotension and acid-base abnormalities should be promptly reversed. Prolonged bed rest is recommended to discourage delayed relapse (30).

Original languageEnglish
Pages (from-to)281-288
Number of pages8
JournalClinical Toxicology
Volume23
Issue number4-6
DOIs
StatePublished - Jan 1 1985

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Carbon Monoxide
Wounds and Injuries
Brain Hypoxia-Ischemia
Recurrence
Hyperbaric Oxygenation
Bed Rest
Oxygenation
Hypotension
Blood
Oxygen
Physicians
Acids
Neuropathology
Therapeutics

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis

Cite this

Carbon monoxide intoxication : Clinical features, neuropathology and mechanisms of injury. / Ginsberg, Myron.

In: Clinical Toxicology, Vol. 23, No. 4-6, 01.01.1985, p. 281-288.

Research output: Contribution to journalArticle

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