TY - JOUR
T1 - Carbon monoxide intoxication
T2 - Clinical features, neuropathology and mechanisms of injury
AU - Ginsberg, Myron D.
N1 - Funding Information:
Dr. Ginsberg's work is supported by NIH Grant NS 05820.
Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 1985
Y1 - 1985
N2 - CO intoxication, by producing cerebral hypoxia-ischaemia, may trigger neuropathological events which result in delayed neurological relapse even in patients whose earlier clinical course has appeared deceptively benign. The physician's index of suspicion must therefore be high, and it should be remembered that, even in major CO exposures, blood COHb levels may be low if a period of several hours has elapsed since exposure. The importance of recognising occult CO exposure (28) and of treating symptomatic patients promptly (29,30) cannot be overemphasised. Immediate administration of high concentrations of inspired oxygen (including hyperbaric oxygenation, if available) is the primary therapy. Hypotension and acid-base abnormalities should be promptly reversed. Prolonged bed rest is recommended to discourage delayed relapse (30).
AB - CO intoxication, by producing cerebral hypoxia-ischaemia, may trigger neuropathological events which result in delayed neurological relapse even in patients whose earlier clinical course has appeared deceptively benign. The physician's index of suspicion must therefore be high, and it should be remembered that, even in major CO exposures, blood COHb levels may be low if a period of several hours has elapsed since exposure. The importance of recognising occult CO exposure (28) and of treating symptomatic patients promptly (29,30) cannot be overemphasised. Immediate administration of high concentrations of inspired oxygen (including hyperbaric oxygenation, if available) is the primary therapy. Hypotension and acid-base abnormalities should be promptly reversed. Prolonged bed rest is recommended to discourage delayed relapse (30).
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U2 - 10.3109/15563658508990635
DO - 10.3109/15563658508990635
M3 - Article
C2 - 4057319
AN - SCOPUS:0021782143
VL - 23
SP - 281
EP - 288
JO - Clinical Toxicology
JF - Clinical Toxicology
SN - 1556-3650
IS - 4-6
ER -