Carbon dots: Promising biomaterials for bone-specific imaging and drug delivery

Zhili Peng, Esmail H. Miyanji, Yiqun Zhou, Joel Pardo, Sajini D. Hettiarachchi, Shanghao Li, Patricia L. Blackwelder, Isaac Skromne, Roger M. Leblanc

Research output: Contribution to journalArticlepeer-review

68 Scopus citations


Bone-related diseases and dysfunctions are heavy burdens on our increasingly aged society. One important strategy to relieve this problem is through early detection and treatment of bone-related diseases. Towards this goal, there has been constant interest in developing novel bone-specific materials for imaging and drug delivery. Currently, however, materials that have high affinity and specificity towards bone are very limited. Carbon dots (C-dots) synthesized from carbon nanopowder bind to calcified bones in vivo with high affinity and specificity. In this study we show that bone binding is highly unique to a specific type of C-dot, and that this binding is non-toxic. Significantly, C-dots derived from other raw materials did not show any bone binding properties. These differences are attributed to the differences in surface chemistry of C-dot preparations, highlighting the heterogeneous nature of C-dots. Importantly, bone-binding by carbon nanopowder derived C-dots is not significantly altered by chemical functionalization of their surface. These unique properties indicate the potential applications of carbon nanopowder-derived C-dots as highly bone-specific bioimaging agents and drug carriers.

Original languageEnglish (US)
Pages (from-to)17533-17543
Number of pages11
Issue number44
StatePublished - Nov 28 2017

ASJC Scopus subject areas

  • Materials Science(all)


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