Carbon dots: Promising biomaterials for bone-specific imaging and drug delivery

Zhili Peng, Esmail H. Miyanji, Yiqun Zhou, Joel Pardo, Sajini D. Hettiarachchi, Shanghao Li, Patricia L. Blackwelder, Isaac Skromne, Roger Leblanc

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Bone-related diseases and dysfunctions are heavy burdens on our increasingly aged society. One important strategy to relieve this problem is through early detection and treatment of bone-related diseases. Towards this goal, there has been constant interest in developing novel bone-specific materials for imaging and drug delivery. Currently, however, materials that have high affinity and specificity towards bone are very limited. Carbon dots (C-dots) synthesized from carbon nanopowder bind to calcified bones in vivo with high affinity and specificity. In this study we show that bone binding is highly unique to a specific type of C-dot, and that this binding is non-toxic. Significantly, C-dots derived from other raw materials did not show any bone binding properties. These differences are attributed to the differences in surface chemistry of C-dot preparations, highlighting the heterogeneous nature of C-dots. Importantly, bone-binding by carbon nanopowder derived C-dots is not significantly altered by chemical functionalization of their surface. These unique properties indicate the potential applications of carbon nanopowder-derived C-dots as highly bone-specific bioimaging agents and drug carriers.

Original languageEnglish (US)
Pages (from-to)17533-17543
Number of pages11
JournalNanoscale
Volume9
Issue number44
DOIs
StatePublished - Nov 28 2017

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Biocompatible Materials
Drug delivery
Biomaterials
Bone
Carbon
Imaging techniques
Drug Carriers
Surface chemistry
Raw materials

ASJC Scopus subject areas

  • Materials Science(all)

Cite this

Peng, Z., Miyanji, E. H., Zhou, Y., Pardo, J., Hettiarachchi, S. D., Li, S., ... Leblanc, R. (2017). Carbon dots: Promising biomaterials for bone-specific imaging and drug delivery. Nanoscale, 9(44), 17533-17543. https://doi.org/10.1039/c7nr05731h

Carbon dots : Promising biomaterials for bone-specific imaging and drug delivery. / Peng, Zhili; Miyanji, Esmail H.; Zhou, Yiqun; Pardo, Joel; Hettiarachchi, Sajini D.; Li, Shanghao; Blackwelder, Patricia L.; Skromne, Isaac; Leblanc, Roger.

In: Nanoscale, Vol. 9, No. 44, 28.11.2017, p. 17533-17543.

Research output: Contribution to journalArticle

Peng, Z, Miyanji, EH, Zhou, Y, Pardo, J, Hettiarachchi, SD, Li, S, Blackwelder, PL, Skromne, I & Leblanc, R 2017, 'Carbon dots: Promising biomaterials for bone-specific imaging and drug delivery', Nanoscale, vol. 9, no. 44, pp. 17533-17543. https://doi.org/10.1039/c7nr05731h
Peng Z, Miyanji EH, Zhou Y, Pardo J, Hettiarachchi SD, Li S et al. Carbon dots: Promising biomaterials for bone-specific imaging and drug delivery. Nanoscale. 2017 Nov 28;9(44):17533-17543. https://doi.org/10.1039/c7nr05731h
Peng, Zhili ; Miyanji, Esmail H. ; Zhou, Yiqun ; Pardo, Joel ; Hettiarachchi, Sajini D. ; Li, Shanghao ; Blackwelder, Patricia L. ; Skromne, Isaac ; Leblanc, Roger. / Carbon dots : Promising biomaterials for bone-specific imaging and drug delivery. In: Nanoscale. 2017 ; Vol. 9, No. 44. pp. 17533-17543.
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