Captropril scintigraphy in the diagnosis of renovascular hypertension

George N Sfakianakis, D. J. Jaffe, J. J. Bourgoignie

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Conventional radionuclide renal scanning is not a suitable test or diagnosing renovascular hypertension (RVH) because of the high rate of false-negative and false-positive results observed in surgically-proven patients with RVH. Recently, the sensitivity and the specificity of renograms have been improved by performing the tests after pretreatment with captopril. It is unclear, however, whether renograms using different radiopharmaceuticals are equally useful. We therefore compared sodium-I-131-o-iodohippurate (HIP) and Tc-99m-diethylene-triamine-pentaacetic acid (DTPA) renal scintigraphy before and after a single oral dose of captopril. Our observations emphasize the value of HIP scintigraphy in evaluating patients with possible renovascular hypertension. The test may be specific by measuring the cortical retention of HIP after captopril pretreatment and may provide a uniquely sensitive indicator which is not shared by DTPA. Further experience is needed to assess the sensitivity of the test, particularly in patients with bilateral disease and patients with a branch stenosis of the renal artery. Its value in predicting normalization of blood pressure after angioplasty or corrective vascular surgery also needs assessment. So far, the results of HIP renography with and without captopril have correlated with the outcome of the hypertension in seven patients subjected to transluminal angioplasty of the renal artery.

Original languageEnglish
JournalKidney International
Volume34
Issue numberSUPPL. 25
StatePublished - Jan 1 1988

Fingerprint

Renovascular Hypertension
Radionuclide Imaging
Captopril
Angioplasty
Radioisotope Renography
Kidney
Renal Artery Obstruction
Acids
Needs Assessment
Radiopharmaceuticals
Renal Artery
Radioisotopes
Blood Vessels
Sodium
Blood Pressure
Hypertension
Sensitivity and Specificity

ASJC Scopus subject areas

  • Nephrology

Cite this

Sfakianakis, G. N., Jaffe, D. J., & Bourgoignie, J. J. (1988). Captropril scintigraphy in the diagnosis of renovascular hypertension. Kidney International, 34(SUPPL. 25).

Captropril scintigraphy in the diagnosis of renovascular hypertension. / Sfakianakis, George N; Jaffe, D. J.; Bourgoignie, J. J.

In: Kidney International, Vol. 34, No. SUPPL. 25, 01.01.1988.

Research output: Contribution to journalArticle

Sfakianakis, GN, Jaffe, DJ & Bourgoignie, JJ 1988, 'Captropril scintigraphy in the diagnosis of renovascular hypertension', Kidney International, vol. 34, no. SUPPL. 25.
Sfakianakis GN, Jaffe DJ, Bourgoignie JJ. Captropril scintigraphy in the diagnosis of renovascular hypertension. Kidney International. 1988 Jan 1;34(SUPPL. 25).
Sfakianakis, George N ; Jaffe, D. J. ; Bourgoignie, J. J. / Captropril scintigraphy in the diagnosis of renovascular hypertension. In: Kidney International. 1988 ; Vol. 34, No. SUPPL. 25.
@article{760819fd2f2346ff9acad84247ca6504,
title = "Captropril scintigraphy in the diagnosis of renovascular hypertension",
abstract = "Conventional radionuclide renal scanning is not a suitable test or diagnosing renovascular hypertension (RVH) because of the high rate of false-negative and false-positive results observed in surgically-proven patients with RVH. Recently, the sensitivity and the specificity of renograms have been improved by performing the tests after pretreatment with captopril. It is unclear, however, whether renograms using different radiopharmaceuticals are equally useful. We therefore compared sodium-I-131-o-iodohippurate (HIP) and Tc-99m-diethylene-triamine-pentaacetic acid (DTPA) renal scintigraphy before and after a single oral dose of captopril. Our observations emphasize the value of HIP scintigraphy in evaluating patients with possible renovascular hypertension. The test may be specific by measuring the cortical retention of HIP after captopril pretreatment and may provide a uniquely sensitive indicator which is not shared by DTPA. Further experience is needed to assess the sensitivity of the test, particularly in patients with bilateral disease and patients with a branch stenosis of the renal artery. Its value in predicting normalization of blood pressure after angioplasty or corrective vascular surgery also needs assessment. So far, the results of HIP renography with and without captopril have correlated with the outcome of the hypertension in seven patients subjected to transluminal angioplasty of the renal artery.",
author = "Sfakianakis, {George N} and Jaffe, {D. J.} and Bourgoignie, {J. J.}",
year = "1988",
month = "1",
day = "1",
language = "English",
volume = "34",
journal = "Kidney International",
issn = "0085-2538",
publisher = "Nature Publishing Group",
number = "SUPPL. 25",

}

TY - JOUR

T1 - Captropril scintigraphy in the diagnosis of renovascular hypertension

AU - Sfakianakis, George N

AU - Jaffe, D. J.

AU - Bourgoignie, J. J.

PY - 1988/1/1

Y1 - 1988/1/1

N2 - Conventional radionuclide renal scanning is not a suitable test or diagnosing renovascular hypertension (RVH) because of the high rate of false-negative and false-positive results observed in surgically-proven patients with RVH. Recently, the sensitivity and the specificity of renograms have been improved by performing the tests after pretreatment with captopril. It is unclear, however, whether renograms using different radiopharmaceuticals are equally useful. We therefore compared sodium-I-131-o-iodohippurate (HIP) and Tc-99m-diethylene-triamine-pentaacetic acid (DTPA) renal scintigraphy before and after a single oral dose of captopril. Our observations emphasize the value of HIP scintigraphy in evaluating patients with possible renovascular hypertension. The test may be specific by measuring the cortical retention of HIP after captopril pretreatment and may provide a uniquely sensitive indicator which is not shared by DTPA. Further experience is needed to assess the sensitivity of the test, particularly in patients with bilateral disease and patients with a branch stenosis of the renal artery. Its value in predicting normalization of blood pressure after angioplasty or corrective vascular surgery also needs assessment. So far, the results of HIP renography with and without captopril have correlated with the outcome of the hypertension in seven patients subjected to transluminal angioplasty of the renal artery.

AB - Conventional radionuclide renal scanning is not a suitable test or diagnosing renovascular hypertension (RVH) because of the high rate of false-negative and false-positive results observed in surgically-proven patients with RVH. Recently, the sensitivity and the specificity of renograms have been improved by performing the tests after pretreatment with captopril. It is unclear, however, whether renograms using different radiopharmaceuticals are equally useful. We therefore compared sodium-I-131-o-iodohippurate (HIP) and Tc-99m-diethylene-triamine-pentaacetic acid (DTPA) renal scintigraphy before and after a single oral dose of captopril. Our observations emphasize the value of HIP scintigraphy in evaluating patients with possible renovascular hypertension. The test may be specific by measuring the cortical retention of HIP after captopril pretreatment and may provide a uniquely sensitive indicator which is not shared by DTPA. Further experience is needed to assess the sensitivity of the test, particularly in patients with bilateral disease and patients with a branch stenosis of the renal artery. Its value in predicting normalization of blood pressure after angioplasty or corrective vascular surgery also needs assessment. So far, the results of HIP renography with and without captopril have correlated with the outcome of the hypertension in seven patients subjected to transluminal angioplasty of the renal artery.

UR - http://www.scopus.com/inward/record.url?scp=0023740989&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023740989&partnerID=8YFLogxK

M3 - Article

C2 - 3054230

AN - SCOPUS:0023740989

VL - 34

JO - Kidney International

JF - Kidney International

SN - 0085-2538

IS - SUPPL. 25

ER -