Cancers in the first-degree relatives of children with brain tumours

K. Hemminki, X. Li, P. Vaittinen, Chuanhui Dong

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

We used the nationwide Swedish Family-Cancer Database with 2060 childhood brain tumours diagnosed in the period 1958-1996 to analyse the risk of this tumour by parental cancers and in siblings of childhood brain tumour probands. Groups of patients were compared by calculating standardized incidence ratios (SIRs) for brain tumours in offspring. 1.3% of brain tumour patients had a parent with nervous system cancer; SIRs were 2.4 and 1.88 for diagnostic ages < 5 and < 15 years, respectively. The data showed distinct patterns of familial risks for childhood brain tumours, the SIR was 10.26 for brain astrocytoma given a parent with meningioma. Parental colon cancer was associated with offspring ependymoma (SIR 3.70), and parental salivary gland cancers with offspring medulloblastoma (SIR 13.33, but two cases only). SIR for sibling nervous system cancer from childhood brain tumour probands was 3.55 up to age 61. (C) 2000 Cancer Research Campaign.

Original languageEnglish
Pages (from-to)407-411
Number of pages5
JournalBritish Journal of Cancer
Volume83
Issue number3
StatePublished - Jul 25 2000
Externally publishedYes

Fingerprint

Brain Neoplasms
Incidence
Neoplasms
Nervous System
Siblings
Salivary Gland Neoplasms
Ependymoma
Medulloblastoma
Astrocytoma
Meningioma
Colonic Neoplasms
Databases
Brain

Keywords

  • Astrocytoma
  • Ependymoma
  • Medulloblastoma
  • Meningioma
  • Second cancer

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Cancers in the first-degree relatives of children with brain tumours. / Hemminki, K.; Li, X.; Vaittinen, P.; Dong, Chuanhui.

In: British Journal of Cancer, Vol. 83, No. 3, 25.07.2000, p. 407-411.

Research output: Contribution to journalArticle

Hemminki, K, Li, X, Vaittinen, P & Dong, C 2000, 'Cancers in the first-degree relatives of children with brain tumours', British Journal of Cancer, vol. 83, no. 3, pp. 407-411.
Hemminki, K. ; Li, X. ; Vaittinen, P. ; Dong, Chuanhui. / Cancers in the first-degree relatives of children with brain tumours. In: British Journal of Cancer. 2000 ; Vol. 83, No. 3. pp. 407-411.
@article{6cc3e47add8a4d22837ddb2199da549c,
title = "Cancers in the first-degree relatives of children with brain tumours",
abstract = "We used the nationwide Swedish Family-Cancer Database with 2060 childhood brain tumours diagnosed in the period 1958-1996 to analyse the risk of this tumour by parental cancers and in siblings of childhood brain tumour probands. Groups of patients were compared by calculating standardized incidence ratios (SIRs) for brain tumours in offspring. 1.3{\%} of brain tumour patients had a parent with nervous system cancer; SIRs were 2.4 and 1.88 for diagnostic ages < 5 and < 15 years, respectively. The data showed distinct patterns of familial risks for childhood brain tumours, the SIR was 10.26 for brain astrocytoma given a parent with meningioma. Parental colon cancer was associated with offspring ependymoma (SIR 3.70), and parental salivary gland cancers with offspring medulloblastoma (SIR 13.33, but two cases only). SIR for sibling nervous system cancer from childhood brain tumour probands was 3.55 up to age 61. (C) 2000 Cancer Research Campaign.",
keywords = "Astrocytoma, Ependymoma, Medulloblastoma, Meningioma, Second cancer",
author = "K. Hemminki and X. Li and P. Vaittinen and Chuanhui Dong",
year = "2000",
month = "7",
day = "25",
language = "English",
volume = "83",
pages = "407--411",
journal = "British Journal of Cancer",
issn = "0007-0920",
publisher = "Nature Publishing Group",
number = "3",

}

TY - JOUR

T1 - Cancers in the first-degree relatives of children with brain tumours

AU - Hemminki, K.

AU - Li, X.

AU - Vaittinen, P.

AU - Dong, Chuanhui

PY - 2000/7/25

Y1 - 2000/7/25

N2 - We used the nationwide Swedish Family-Cancer Database with 2060 childhood brain tumours diagnosed in the period 1958-1996 to analyse the risk of this tumour by parental cancers and in siblings of childhood brain tumour probands. Groups of patients were compared by calculating standardized incidence ratios (SIRs) for brain tumours in offspring. 1.3% of brain tumour patients had a parent with nervous system cancer; SIRs were 2.4 and 1.88 for diagnostic ages < 5 and < 15 years, respectively. The data showed distinct patterns of familial risks for childhood brain tumours, the SIR was 10.26 for brain astrocytoma given a parent with meningioma. Parental colon cancer was associated with offspring ependymoma (SIR 3.70), and parental salivary gland cancers with offspring medulloblastoma (SIR 13.33, but two cases only). SIR for sibling nervous system cancer from childhood brain tumour probands was 3.55 up to age 61. (C) 2000 Cancer Research Campaign.

AB - We used the nationwide Swedish Family-Cancer Database with 2060 childhood brain tumours diagnosed in the period 1958-1996 to analyse the risk of this tumour by parental cancers and in siblings of childhood brain tumour probands. Groups of patients were compared by calculating standardized incidence ratios (SIRs) for brain tumours in offspring. 1.3% of brain tumour patients had a parent with nervous system cancer; SIRs were 2.4 and 1.88 for diagnostic ages < 5 and < 15 years, respectively. The data showed distinct patterns of familial risks for childhood brain tumours, the SIR was 10.26 for brain astrocytoma given a parent with meningioma. Parental colon cancer was associated with offspring ependymoma (SIR 3.70), and parental salivary gland cancers with offspring medulloblastoma (SIR 13.33, but two cases only). SIR for sibling nervous system cancer from childhood brain tumour probands was 3.55 up to age 61. (C) 2000 Cancer Research Campaign.

KW - Astrocytoma

KW - Ependymoma

KW - Medulloblastoma

KW - Meningioma

KW - Second cancer

UR - http://www.scopus.com/inward/record.url?scp=0033917820&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033917820&partnerID=8YFLogxK

M3 - Article

C2 - 10917560

AN - SCOPUS:0033917820

VL - 83

SP - 407

EP - 411

JO - British Journal of Cancer

JF - British Journal of Cancer

SN - 0007-0920

IS - 3

ER -