Cancer metastasis: selectable traits without genetic constraints

Research output: Contribution to journalComment/debatepeer-review

1 Scopus citations


Widely metastatic cancers progress rapidly despite sharing genetic drivers with the primary tumor that seeds them. Our recent work indicates that metastatic pancreatic cancers evolve unique metabolic adaptations that are not genetically encoded. These adaptations harness niche-refined nutrients, such as hepatic glucose, to fuel malignant metaboloepigenetic programs that support widespread metastatic outgrowth.

Original languageEnglish (US)
Article number1825910
JournalMolecular and Cellular Oncology
Issue number6
StatePublished - Nov 1 2020
Externally publishedYes


  • Cancer
  • chromatin
  • epigenetics
  • metabolism
  • metastasis

ASJC Scopus subject areas

  • Molecular Medicine
  • Cancer Research


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