Cancer metastasis: selectable traits without genetic constraints

Research output: Contribution to journalComment/debatepeer-review

1 Scopus citations

Abstract

Widely metastatic cancers progress rapidly despite sharing genetic drivers with the primary tumor that seeds them. Our recent work indicates that metastatic pancreatic cancers evolve unique metabolic adaptations that are not genetically encoded. These adaptations harness niche-refined nutrients, such as hepatic glucose, to fuel malignant metaboloepigenetic programs that support widespread metastatic outgrowth.

Original languageEnglish (US)
Article number1825910
JournalMolecular and Cellular Oncology
Volume7
Issue number6
DOIs
StatePublished - Nov 1 2020
Externally publishedYes

Keywords

  • Cancer
  • chromatin
  • epigenetics
  • metabolism
  • metastasis

ASJC Scopus subject areas

  • Molecular Medicine
  • Cancer Research

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