Cancer Markers: Integratively annotated classification

M. Orsini, A. Travaglione, E. Capobianco

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Translational cancer genomics research aims to ensure that experimental knowledge is subject to computational analysis, and integrated with a variety of records from omics and clinical sources. The data retrieval from such sources is not trivial, due to their redundancy and heterogeneity, and the presence of false evidence. In silico marker identification, therefore, remains a complex task that is mainly motivated by the impact that target identification from the elucidation of gene co-expression dynamics and regulation mechanisms, combined with the discovery of genotype-phenotype associations, may have for clinical validation. Based on the reuse of publicly available gene expression data, our aim is to propose cancer marker classification by integrating the prediction power of multiple annotation sources. In particular, with reference to the functional annotation for colorectal markers, we indicate a classification of markers into diagnostic and prognostic classes combined with susceptibility and risk factors.

Original languageEnglish (US)
Pages (from-to)257-265
Number of pages9
JournalGene
Volume530
Issue number2
DOIs
StatePublished - Nov 10 2013

Keywords

  • Clinical re-annotation
  • Marker classification
  • Translational cancer genomics

ASJC Scopus subject areas

  • Genetics

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