Can Neurochemical Changes of Mood Disorders Explain the Increase Risk of Epilepsy or its Worse Seizure Control?

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

The existence of a bidirectional relation between mood disorders and epilepsy has been suggested by six population-based studies. Furthermore, three studies have associated a higher risk of treatment-resistant epilepsy with a history of depression preceding the onset of epilepsy. Common pathogenic mechanisms operant in depression and epilepsy may provide a possible explanation of these observations. This article reviews some of the leading pathogenic mechanisms of depression with respect to potential proconvulsant properties that may provide explanations for these phenomena.

Original languageEnglish (US)
Pages (from-to)2071-2076
Number of pages6
JournalNeurochemical Research
Volume42
Issue number7
DOIs
StatePublished - Jul 1 2017

Keywords

  • Cortisol
  • GABA
  • Glutamate
  • Major depressive disorders
  • Serotonin
  • Treatment-resistant epilepsy

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

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