Can mammographic and sonographic imaging features predict the Oncotype DX™ recurrence score in T1 and T2, hormone receptor positive, HER2 negative and axillary lymph node negative breast cancers?

Monica Maria Yepes, Ada Pat Romilly, Fernando Collado-Mesa, Jose Miguel Net, Richard A Kiszonas, Kristopher Arheart, Daniel Young, Stefan Gluck

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

To determine whether mammographic or sonographic features can predict the Oncotype DX™ recurrence scores (RS) in patients with TI–II, hormone receptor (HR) positive, HER2/neu negative and node negative breast cancers. Institutional board review was obtained and informed consent was waived for this retrospective study. Seventy-eight patients with stage I–II invasive breast cancer that was HR positive, HER2 negative, and lymph node negative for whom mammographic and or sonographic imaging and Oncotype DX™ assay scores were available were included in the study Four breast dedicated radiologists blinded to the RS retrospectively described the lesions according to BI-RADS lexicon descriptors. Multivariable logistic regression was used to test for significant independent predictors of low (<18) versus intermediate to high range (≥18). Two imaging features reached statistical significance in predicting low from intermediate or high risk RS: pleomorphic microcalcifications within a mass (P = 0.017); OR 8.37, 95 % CI (1.47–47.79) on mammography and posterior acoustic enhancement in a mass on ultrasound (P = 0.048); OR 4.35, 95 % CI (1.01–18.73) on multivariable logistic regression. A mass with pleomorphic microcalcifications on mammography or the presence of posterior acoustic enhancement on ultrasound may predict an intermediate to high RS as determined by the Oncotype DXTM assay in patients with stage I–II HR positive, HER2 negative, and lymph node negative invasive breast cancer.

Original languageEnglish
Pages (from-to)117-123
Number of pages7
JournalBreast Cancer Research and Treatment
Volume148
Issue number1
DOIs
StatePublished - Jan 1 2014

Keywords

  • Breast imaging
  • Imaging correlation
  • Mammography
  • Oncotype DX
  • Oncotype DX recurrence score
  • Ultrasound

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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