Can Chromatin Accessibility be Exploited for Axon Regeneration?

Matt C. Danzi, Nick O’Neill, John Bixby, Vance Lemmon

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Several studies have demonstrated that the intrinsic ability of neurons to regenerate their axons can be stimulated by maneuvers that favor the open state of chromatin, such as inhibiting histone deacetylase activity or increasing histone acetyltransferase activity. Taken together, these experiments suggest that axon regenerative ability can be increased by promoting chromatin accessibility. In this article, we assess the direct evidence in the literature for this hypothesis and re-examine other axon regeneration-promoting manipulations to see if they provide additional support. We find that several interventions known to enhance intrinsic axonal growth capability also increase chromatin accessibility. Although the support for this correlation is strong in the literature, we conclude with a word of caution about therapeutics attempting to exploit this relationship.

Original languageEnglish (US)
JournalDevelopmental Neurobiology
DOIs
StateAccepted/In press - Jan 1 2018

Fingerprint

Chromatin
Axons
Regeneration
Histone Acetyltransferases
Histone Deacetylases
Neurons
Growth
Therapeutics

Keywords

  • epigenetics
  • neuron
  • neuronal activity
  • PTEN
  • TET3

ASJC Scopus subject areas

  • Developmental Neuroscience
  • Cellular and Molecular Neuroscience

Cite this

Can Chromatin Accessibility be Exploited for Axon Regeneration? / Danzi, Matt C.; O’Neill, Nick; Bixby, John; Lemmon, Vance.

In: Developmental Neurobiology, 01.01.2018.

Research output: Contribution to journalArticle

@article{edec0833dbc7497c8f3826d123000cd5,
title = "Can Chromatin Accessibility be Exploited for Axon Regeneration?",
abstract = "Several studies have demonstrated that the intrinsic ability of neurons to regenerate their axons can be stimulated by maneuvers that favor the open state of chromatin, such as inhibiting histone deacetylase activity or increasing histone acetyltransferase activity. Taken together, these experiments suggest that axon regenerative ability can be increased by promoting chromatin accessibility. In this article, we assess the direct evidence in the literature for this hypothesis and re-examine other axon regeneration-promoting manipulations to see if they provide additional support. We find that several interventions known to enhance intrinsic axonal growth capability also increase chromatin accessibility. Although the support for this correlation is strong in the literature, we conclude with a word of caution about therapeutics attempting to exploit this relationship.",
keywords = "epigenetics, neuron, neuronal activity, PTEN, TET3",
author = "Danzi, {Matt C.} and Nick O’Neill and John Bixby and Vance Lemmon",
year = "2018",
month = "1",
day = "1",
doi = "10.1002/dneu.22598",
language = "English (US)",
journal = "Developmental Neurobiology",
issn = "0022-3034",
publisher = "John Wiley and Sons Inc.",

}

TY - JOUR

T1 - Can Chromatin Accessibility be Exploited for Axon Regeneration?

AU - Danzi, Matt C.

AU - O’Neill, Nick

AU - Bixby, John

AU - Lemmon, Vance

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Several studies have demonstrated that the intrinsic ability of neurons to regenerate their axons can be stimulated by maneuvers that favor the open state of chromatin, such as inhibiting histone deacetylase activity or increasing histone acetyltransferase activity. Taken together, these experiments suggest that axon regenerative ability can be increased by promoting chromatin accessibility. In this article, we assess the direct evidence in the literature for this hypothesis and re-examine other axon regeneration-promoting manipulations to see if they provide additional support. We find that several interventions known to enhance intrinsic axonal growth capability also increase chromatin accessibility. Although the support for this correlation is strong in the literature, we conclude with a word of caution about therapeutics attempting to exploit this relationship.

AB - Several studies have demonstrated that the intrinsic ability of neurons to regenerate their axons can be stimulated by maneuvers that favor the open state of chromatin, such as inhibiting histone deacetylase activity or increasing histone acetyltransferase activity. Taken together, these experiments suggest that axon regenerative ability can be increased by promoting chromatin accessibility. In this article, we assess the direct evidence in the literature for this hypothesis and re-examine other axon regeneration-promoting manipulations to see if they provide additional support. We find that several interventions known to enhance intrinsic axonal growth capability also increase chromatin accessibility. Although the support for this correlation is strong in the literature, we conclude with a word of caution about therapeutics attempting to exploit this relationship.

KW - epigenetics

KW - neuron

KW - neuronal activity

KW - PTEN

KW - TET3

UR - http://www.scopus.com/inward/record.url?scp=85052830413&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85052830413&partnerID=8YFLogxK

U2 - 10.1002/dneu.22598

DO - 10.1002/dneu.22598

M3 - Article

C2 - 29664188

AN - SCOPUS:85052830413

JO - Developmental Neurobiology

JF - Developmental Neurobiology

SN - 0022-3034

ER -