Calculation of corneal temperature and shrinkage during Laser ThermoKeratoplasty (LTK)

Research output: Chapter in Book/Report/Conference proceedingConference contribution

5 Citations (Scopus)

Abstract

Purpose. The purpose of this study was to develop a model to predict the come al temperature and shrinkage during laser thermokeratoplasty and other clinical procedures relying on laser-induced thermal shrinkage of collagenous tissue. Methods. The corneal temperature was calculated by solving the bio-heat equation during laser irradiation using a semi-analytical technique. To calculate shrinkage, we assumed that corneal thermal shrinkage is a thermal denaturation process that follows an Arrhenius equation, and that shrinkage resulting from denaturation is proportional to the amount of thermal damage. We calculated shrinkage for pulsed Ho:YAG laser thermokeratoplasty using the clinical treatment algorithm. Results. The thermal model predicts that the corneal temperature reaches values that may be high enough to induce surface vaporization of the epithelium and thermal damage of the endothelium. Shrinkage calculations show that significant shrinkage is produced only after the third laser pulse. Shrinkage is produced mainly during laser pulses and stops shortly after the start of the cooling phase between laser pulses. Conclusions. These calculations demonstrate that thermal shrinkage can be predicted by combining an optical-thermal model and a thermal denaturation model. Accurate quantitative prediction of the shrinkage effect requires a better knowledge of the dynamics of shrinkage and of the optical thermal response of the cornea.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsF. Manns, P.G. Soderberg, A. Ho
Pages101-109
Number of pages9
Volume4611
DOIs
StatePublished - 2002
EventOphthalmic Technologies XII - San Jose, CA, United States
Duration: Jan 19 2002Jan 20 2002

Other

OtherOphthalmic Technologies XII
CountryUnited States
CitySan Jose, CA
Period1/19/021/20/02

Fingerprint

shrinkage
Lasers
lasers
Temperature
Denaturation
temperature
biopolymer denaturation
Laser pulses
Hot Temperature
pulses
damage
endothelium
cornea
epithelium
Laser beam effects
Vaporization
YAG lasers
pulsed lasers
Tissue
Cooling

Keywords

  • Collagen
  • Laser
  • Laser-tissue interaction
  • Model
  • Shrinkage
  • Thermal
  • Thermokeratoplasty

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

Cite this

Manns, F., Borja, D., & Parel, J-M. A. (2002). Calculation of corneal temperature and shrinkage during Laser ThermoKeratoplasty (LTK). In F. Manns, P. G. Soderberg, & A. Ho (Eds.), Proceedings of SPIE - The International Society for Optical Engineering (Vol. 4611, pp. 101-109) https://doi.org/10.1117/12.470581

Calculation of corneal temperature and shrinkage during Laser ThermoKeratoplasty (LTK). / Manns, Fabrice; Borja, David; Parel, Jean-Marie A.

Proceedings of SPIE - The International Society for Optical Engineering. ed. / F. Manns; P.G. Soderberg; A. Ho. Vol. 4611 2002. p. 101-109.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Manns, F, Borja, D & Parel, J-MA 2002, Calculation of corneal temperature and shrinkage during Laser ThermoKeratoplasty (LTK). in F Manns, PG Soderberg & A Ho (eds), Proceedings of SPIE - The International Society for Optical Engineering. vol. 4611, pp. 101-109, Ophthalmic Technologies XII, San Jose, CA, United States, 1/19/02. https://doi.org/10.1117/12.470581
Manns F, Borja D, Parel J-MA. Calculation of corneal temperature and shrinkage during Laser ThermoKeratoplasty (LTK). In Manns F, Soderberg PG, Ho A, editors, Proceedings of SPIE - The International Society for Optical Engineering. Vol. 4611. 2002. p. 101-109 https://doi.org/10.1117/12.470581
Manns, Fabrice ; Borja, David ; Parel, Jean-Marie A. / Calculation of corneal temperature and shrinkage during Laser ThermoKeratoplasty (LTK). Proceedings of SPIE - The International Society for Optical Engineering. editor / F. Manns ; P.G. Soderberg ; A. Ho. Vol. 4611 2002. pp. 101-109
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AB - Purpose. The purpose of this study was to develop a model to predict the come al temperature and shrinkage during laser thermokeratoplasty and other clinical procedures relying on laser-induced thermal shrinkage of collagenous tissue. Methods. The corneal temperature was calculated by solving the bio-heat equation during laser irradiation using a semi-analytical technique. To calculate shrinkage, we assumed that corneal thermal shrinkage is a thermal denaturation process that follows an Arrhenius equation, and that shrinkage resulting from denaturation is proportional to the amount of thermal damage. We calculated shrinkage for pulsed Ho:YAG laser thermokeratoplasty using the clinical treatment algorithm. Results. The thermal model predicts that the corneal temperature reaches values that may be high enough to induce surface vaporization of the epithelium and thermal damage of the endothelium. Shrinkage calculations show that significant shrinkage is produced only after the third laser pulse. Shrinkage is produced mainly during laser pulses and stops shortly after the start of the cooling phase between laser pulses. Conclusions. These calculations demonstrate that thermal shrinkage can be predicted by combining an optical-thermal model and a thermal denaturation model. Accurate quantitative prediction of the shrinkage effect requires a better knowledge of the dynamics of shrinkage and of the optical thermal response of the cornea.

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