Calcium/calmodulin-dependent protein kinase mediates a pathway for transcriptional regulation

Michael S Kapiloff, J. Michael Mathis, Charles A. Nelson, Chijen R. Lin, Michael G. Rosenfeld

Research output: Contribution to journalArticle

105 Citations (Scopus)

Abstract

Calcium influx in response to extracellular signals can modulate gene transcription. A constitutive, calcium/calmodulin-independent mutant of type II calcium/ calmodulin-dependent protein kinase was capable of increasing the transcription rate of specific genes independently of protein kinase C activation. This increase was mediated by transferrable cis-active elements capable of binding the transcription factor CAAT/enhancer binding protein. Therefore, the activation of type II calcium/calmodulin-dependent protein kinase in response to stimuli that increase intracellular calcium is proposed to represent a distinct second messenger pathway in calcium-mediated regulation of gene transcription.

Original languageEnglish
Pages (from-to)3710-3714
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume88
Issue number9
StatePublished - Dec 1 1991
Externally publishedYes

Fingerprint

Calcium-Calmodulin-Dependent Protein Kinases
Calcium
CCAAT-Enhancer-Binding Proteins
Second Messenger Systems
Calmodulin
Protein Kinase C
Genes
Transcription Factors
Proteins

Keywords

  • CAAT
  • Enhancer binding protein
  • Long terminal repeat
  • Prolactin gene
  • Rous sarcoma virus

ASJC Scopus subject areas

  • General
  • Genetics

Cite this

Calcium/calmodulin-dependent protein kinase mediates a pathway for transcriptional regulation. / Kapiloff, Michael S; Mathis, J. Michael; Nelson, Charles A.; Lin, Chijen R.; Rosenfeld, Michael G.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 88, No. 9, 01.12.1991, p. 3710-3714.

Research output: Contribution to journalArticle

Kapiloff, Michael S ; Mathis, J. Michael ; Nelson, Charles A. ; Lin, Chijen R. ; Rosenfeld, Michael G. / Calcium/calmodulin-dependent protein kinase mediates a pathway for transcriptional regulation. In: Proceedings of the National Academy of Sciences of the United States of America. 1991 ; Vol. 88, No. 9. pp. 3710-3714.
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