Calcium modulation and high calcium permeability of neuronal nicotinic acetylcholine receptors

Steven Vernino, Mariano Amador, Charles W Luetje, Jim Patrick, John A. Dani

Research output: Contribution to journalArticle

377 Citations (Scopus)

Abstract

Two properties were found to distinguish neuronal from muscle nicotinic acetylcholine receptors (nAChRs). First, neuronal nAChRs have a greater Ca 2+ permeability. The high Ca2+ flux through neuronal nAChRs activates a Ca2+-dependent CI- conductance, and the Ca 2+ to Cs+ permeability ratio ( PCa PCs) is 7 times greater for neuronal than for muscle nAChRs. A second difference between the receptor types is that neuronal nAChRs are potently modulated by physiological levels of external Ca 2+. Neuronal nAChR currents are enhanced by external Ca2+ in a dose-dependent manner. The results indicate that changes in extracellular Call modulate neuronal nAChRs and may modulate cholinergic synapses in the CNS. Also, activation of neuronal nAChRs produces a significant influx of Ca2+ that could be an important intracellular signal.

Original languageEnglish
Pages (from-to)127-134
Number of pages8
JournalNeuron
Volume8
Issue number1
DOIs
StatePublished - Jan 1 1992
Externally publishedYes

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Nicotinic Receptors
Permeability
Calcium
Muscles
Synapses
Cholinergic Agents

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Calcium modulation and high calcium permeability of neuronal nicotinic acetylcholine receptors. / Vernino, Steven; Amador, Mariano; Luetje, Charles W; Patrick, Jim; Dani, John A.

In: Neuron, Vol. 8, No. 1, 01.01.1992, p. 127-134.

Research output: Contribution to journalArticle

Vernino, S, Amador, M, Luetje, CW, Patrick, J & Dani, JA 1992, 'Calcium modulation and high calcium permeability of neuronal nicotinic acetylcholine receptors', Neuron, vol. 8, no. 1, pp. 127-134. https://doi.org/10.1016/0896-6273(92)90114-S
Vernino, Steven ; Amador, Mariano ; Luetje, Charles W ; Patrick, Jim ; Dani, John A. / Calcium modulation and high calcium permeability of neuronal nicotinic acetylcholine receptors. In: Neuron. 1992 ; Vol. 8, No. 1. pp. 127-134.
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