TY - JOUR
T1 - Calcium is required for the mitogenic activation of lymphocytes by periodic acid oxidation
AU - Hornicek, Francis J.
AU - Malinin, George I.
AU - Malinin, Theodore I.
PY - 1992/2/28
Y1 - 1992/2/28
N2 - This investigation of Ca2+ requirements for the mitogenic activation of lymphocytes by periodic acid has shown that oxidation by periodate causes an immediate and transient increase of Ca2+ influx and efflux in oxidized cells. Oxidized lymphocytes maintained in the medium containing 0.2 mM Ca2+ failed to proliferate or to produce IL-2, whereas a 1.4 mM Ca2+ concentration was shown to be sufficient to sustain cellular proliferation and IL-2 secretion. These results indicate that mitogenic activation of lymphocytes by periodic acid oxidation is Ca2+-dependent.
AB - This investigation of Ca2+ requirements for the mitogenic activation of lymphocytes by periodic acid has shown that oxidation by periodate causes an immediate and transient increase of Ca2+ influx and efflux in oxidized cells. Oxidized lymphocytes maintained in the medium containing 0.2 mM Ca2+ failed to proliferate or to produce IL-2, whereas a 1.4 mM Ca2+ concentration was shown to be sufficient to sustain cellular proliferation and IL-2 secretion. These results indicate that mitogenic activation of lymphocytes by periodic acid oxidation is Ca2+-dependent.
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U2 - 10.1016/0006-291X(92)91620-6
DO - 10.1016/0006-291X(92)91620-6
M3 - Article
C2 - 1311920
AN - SCOPUS:0026573916
VL - 183
SP - 144
EP - 149
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
SN - 0006-291X
IS - 1
ER -