Calcium is required for the mitogenic activation of lymphocytes by periodic acid oxidation

Francis J. Hornicek, George I. Malinin, Theodore I. Malinin

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

This investigation of Ca2+ requirements for the mitogenic activation of lymphocytes by periodic acid has shown that oxidation by periodate causes an immediate and transient increase of Ca2+ influx and efflux in oxidized cells. Oxidized lymphocytes maintained in the medium containing 0.2 mM Ca2+ failed to proliferate or to produce IL-2, whereas a 1.4 mM Ca2+ concentration was shown to be sufficient to sustain cellular proliferation and IL-2 secretion. These results indicate that mitogenic activation of lymphocytes by periodic acid oxidation is Ca2+-dependent.

Original languageEnglish (US)
Pages (from-to)144-149
Number of pages6
JournalBiochemical and biophysical research communications
Volume183
Issue number1
DOIs
StatePublished - Feb 28 1992

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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