Calcium is required for the mitogenic activation of lymphocytes by periodic acid oxidation

Francis J. Hornicek; George I. Malinin; Theodore I. Malinin

doi:10.1016/0006-291X(92)91620-6

Calcium is required for the mitogenic activation of lymphocytes by periodic acid oxidation

Francis J. Hornicek, George I. Malinin, Theodore I. Malinin

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3 Scopus citations

Abstract

This investigation of Ca²⁺ requirements for the mitogenic activation of lymphocytes by periodic acid has shown that oxidation by periodate causes an immediate and transient increase of Ca²⁺ influx and efflux in oxidized cells. Oxidized lymphocytes maintained in the medium containing 0.2 mM Ca²⁺ failed to proliferate or to produce IL-2, whereas a 1.4 mM Ca²⁺ concentration was shown to be sufficient to sustain cellular proliferation and IL-2 secretion. These results indicate that mitogenic activation of lymphocytes by periodic acid oxidation is Ca²⁺-dependent.

Original language	English (US)
Pages (from-to)	144-149
Number of pages	6
Journal	Biochemical and biophysical research communications
Volume	183
Issue number	1
DOIs	https://doi.org/10.1016/0006-291X(92)91620-6
State	Published - Feb 28 1992

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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Hornicek, F. J., Malinin, G. I., & Malinin, T. I. (1992). Calcium is required for the mitogenic activation of lymphocytes by periodic acid oxidation. Biochemical and biophysical research communications, 183(1), 144-149. https://doi.org/10.1016/0006-291X(92)91620-6

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