Calcium content of RBCs from patients with amyotrophic lateral sclerosis

M. T. Felmus, C. G. Rasool, Walter G Bradley

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Our results showed no difference between the calcium concentration in whole RBCs and their membrane fractions from patients with classic ALS and normal control subjects. This finding seems to exclude a generalized calcium abnormality in ALS. The possibility still exists, however, that the anterior horn cells may accumulate Ca++ that may act as a metabolic 'poison' and lead to cell death. Normal RBC calcium content does not exclude abnormalities in membrane structure and function. For example, calcium-uptake kinetics could be impaired with normal intracellular concentration. Further biochemical and physiologic analyses of RBC membranes are needed before a generalized membrane defect, which might affect anterior horn cells, can be excluded.

Original languageEnglish
JournalArchives of Neurology
Volume39
Issue number7
StatePublished - Dec 1 1982
Externally publishedYes

Fingerprint

Amyotrophic Lateral Sclerosis
Anterior Horn Cells
Calcium
Membranes
Poisons
Cell Death
Membrane
Cells

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Calcium content of RBCs from patients with amyotrophic lateral sclerosis. / Felmus, M. T.; Rasool, C. G.; Bradley, Walter G.

In: Archives of Neurology, Vol. 39, No. 7, 01.12.1982.

Research output: Contribution to journalArticle

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