Calcium Content of RBCs From Patients With Amyotrophic Lateral Sclerosis

Mark T. Felmus, Chaudri G. Rasool, Walter G. Bradley

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Our results showed no difference between the calcium concentration in whole RBCs and their membrane fractions from patients with classic ALS and normal control subjects. This finding seems to exclude a generalized calcium abnormality in ALS. The possibility still exists, however, that the anterior horn cells may accumulate Ca++ that may act as a metabolic 'poison' and lead to cell death. Normal RBC calcium content does not exclude abnormalities in membrane structure and function. For example, calcium-uptake kinetics could be impaired with normal intracellular concentration. Further biochemical and physiologic analyses of RBC membranes are needed before a generalized membrane defect, which might affect anterior horn cells, can be excluded.

Original languageEnglish (US)
Number of pages1
JournalArchives of neurology
Volume39
Issue number7
DOIs
StatePublished - Jul 1982
Externally publishedYes

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology

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