Our results showed no difference between the calcium concentration in whole RBCs and their membrane fractions from patients with classic ALS and normal control subjects. This finding seems to exclude a generalized calcium abnormality in ALS. The possibility still exists, however, that the anterior horn cells may accumulate Ca++ that may act as a metabolic 'poison' and lead to cell death. Normal RBC calcium content does not exclude abnormalities in membrane structure and function. For example, calcium-uptake kinetics could be impaired with normal intracellular concentration. Further biochemical and physiologic analyses of RBC membranes are needed before a generalized membrane defect, which might affect anterior horn cells, can be excluded.
|Original language||English (US)|
|Number of pages||1|
|Journal||Archives of neurology|
|State||Published - Jul 1982|
ASJC Scopus subject areas
- Arts and Humanities (miscellaneous)
- Clinical Neurology