Calcium channel blockers

T. Ahmed

Research output: Contribution to journalReview article

Abstract

Mediator release, synthesis of some newly formed mediators, airway smooth muscle contraction, and nerve-impulse conduction are all dependent on the availability and flux of Ca2+. It is likely that Ca2+ antagonists modify allergic bronchoconstriction. Ca2+ antagonists in vitro have been shown to inhibit synthesis and/or release of mediators and attenuate airway smooth muscle contraction. In vivo effects of Ca2+ antagonists are variable. Currently available Ca2+ antagonists are of limited value in the treatment of asthma. It is hoped that newer potent agents when administered via inhaled route may be of potential use.

Original languageEnglish (US)
Pages (from-to)515-530
Number of pages16
JournalImmunology and Allergy Clinics of North America
Volume10
Issue number3
StatePublished - Jan 1 1990

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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