Calcium channel blockers

T. Ahmed

Research output: Contribution to journalArticle

Abstract

Mediator release, synthesis of some newly formed mediators, airway smooth muscle contraction, and nerve-impulse conduction are all dependent on the availability and flux of Ca2+. It is likely that Ca2+ antagonists modify allergic bronchoconstriction. Ca2+ antagonists in vitro have been shown to inhibit synthesis and/or release of mediators and attenuate airway smooth muscle contraction. In vivo effects of Ca2+ antagonists are variable. Currently available Ca2+ antagonists are of limited value in the treatment of asthma. It is hoped that newer potent agents when administered via inhaled route may be of potential use.

Original languageEnglish
Pages (from-to)515-530
Number of pages16
JournalImmunology and Allergy Clinics of North America
Volume10
Issue number3
StatePublished - Jan 1 1990
Externally publishedYes

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Calcium Channel Blockers
Muscle Contraction
Smooth Muscle
Bronchoconstriction
Neural Conduction
Action Potentials
Asthma
In Vitro Techniques

ASJC Scopus subject areas

  • Immunology and Allergy

Cite this

Calcium channel blockers. / Ahmed, T.

In: Immunology and Allergy Clinics of North America, Vol. 10, No. 3, 01.01.1990, p. 515-530.

Research output: Contribution to journalArticle

Ahmed, T 1990, 'Calcium channel blockers', Immunology and Allergy Clinics of North America, vol. 10, no. 3, pp. 515-530.
Ahmed, T. / Calcium channel blockers. In: Immunology and Allergy Clinics of North America. 1990 ; Vol. 10, No. 3. pp. 515-530.
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