Calcium-activated potassium channels

A. L. Blatz, K. L. Magleby

Research output: Contribution to journalArticle

291 Scopus citations

Abstract

Ca2+-activated K+ currents are found in most types of cells. Considerable progress has been made since the development of single channel recording techniques in identifying some of the channels underlying these currents. It is now apparent that there are many types of Ca2+-activated K+ channels, which differ in their conductances and sensitivity to activation by both [Ca2+]i and voltage. Ca2+-activated K+ channels couple Ca2+ metabolism and membrane potential to K+ flux and membrane excitability. Ca2+-activated K+ channels allow and modulate repetitive firing in some neurons and contribute to regulation of secretion in some endocrine and exocrine cells.

Original languageEnglish (US)
Pages (from-to)463-467
Number of pages5
JournalTrends in Neurosciences
Volume10
Issue number11
DOIs
StatePublished - Nov 1987

ASJC Scopus subject areas

  • Neuroscience(all)

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