Calcitonin secretion in vitro. III. Synergistic secretory effects of enteric polypeptide hormones

B. A. Roos

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Crude and highly purified preparations of enteric peptide hormones were shown to stimulate trout calcitonin (tCT) secretion in vitro. Since the maximal stimulatory effects of crude pancreozymin/secretin preparations were seen to be greater than the secretory effects obtained with the individual purified enteric peptides, the current study has focused on the secretory effects of several combinations of enteric peptides. The additive and synergistic secretory effects of various specific peptide combinations are demonstrated. Marked (85-fold) stimulation of tCT secretion occurs in response to combinations of synthetic secretin (5 x 10-5M) with pentagastrin (10-6M) or the carboxyl-terminal octapeptide of pancreozymin (10-6M). These findings have significance with regard to the potentiation of hormone action, and are preliminary evidence for the presence of separate receptors for various enteric peptide secretagogues on C-cells.

Original languageEnglish
Pages (from-to)1679-1683
Number of pages5
JournalEndocrinology
Volume100
Issue number6
StatePublished - Dec 1 1977

Fingerprint

Gastrointestinal Hormones
Peptide Hormones
Calcitonin
Peptides
Secretin
Trout
Cholecystokinin
Pentagastrin
Hormones
In Vitro Techniques

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Calcitonin secretion in vitro. III. Synergistic secretory effects of enteric polypeptide hormones. / Roos, B. A.

In: Endocrinology, Vol. 100, No. 6, 01.12.1977, p. 1679-1683.

Research output: Contribution to journalArticle

@article{f2776bca3c89459c904b5ac5238a8ac7,
title = "Calcitonin secretion in vitro. III. Synergistic secretory effects of enteric polypeptide hormones",
abstract = "Crude and highly purified preparations of enteric peptide hormones were shown to stimulate trout calcitonin (tCT) secretion in vitro. Since the maximal stimulatory effects of crude pancreozymin/secretin preparations were seen to be greater than the secretory effects obtained with the individual purified enteric peptides, the current study has focused on the secretory effects of several combinations of enteric peptides. The additive and synergistic secretory effects of various specific peptide combinations are demonstrated. Marked (85-fold) stimulation of tCT secretion occurs in response to combinations of synthetic secretin (5 x 10-5M) with pentagastrin (10-6M) or the carboxyl-terminal octapeptide of pancreozymin (10-6M). These findings have significance with regard to the potentiation of hormone action, and are preliminary evidence for the presence of separate receptors for various enteric peptide secretagogues on C-cells.",
author = "Roos, {B. A.}",
year = "1977",
month = "12",
day = "1",
language = "English",
volume = "100",
pages = "1679--1683",
journal = "Endocrinology",
issn = "0013-7227",
publisher = "The Endocrine Society",
number = "6",

}

TY - JOUR

T1 - Calcitonin secretion in vitro. III. Synergistic secretory effects of enteric polypeptide hormones

AU - Roos, B. A.

PY - 1977/12/1

Y1 - 1977/12/1

N2 - Crude and highly purified preparations of enteric peptide hormones were shown to stimulate trout calcitonin (tCT) secretion in vitro. Since the maximal stimulatory effects of crude pancreozymin/secretin preparations were seen to be greater than the secretory effects obtained with the individual purified enteric peptides, the current study has focused on the secretory effects of several combinations of enteric peptides. The additive and synergistic secretory effects of various specific peptide combinations are demonstrated. Marked (85-fold) stimulation of tCT secretion occurs in response to combinations of synthetic secretin (5 x 10-5M) with pentagastrin (10-6M) or the carboxyl-terminal octapeptide of pancreozymin (10-6M). These findings have significance with regard to the potentiation of hormone action, and are preliminary evidence for the presence of separate receptors for various enteric peptide secretagogues on C-cells.

AB - Crude and highly purified preparations of enteric peptide hormones were shown to stimulate trout calcitonin (tCT) secretion in vitro. Since the maximal stimulatory effects of crude pancreozymin/secretin preparations were seen to be greater than the secretory effects obtained with the individual purified enteric peptides, the current study has focused on the secretory effects of several combinations of enteric peptides. The additive and synergistic secretory effects of various specific peptide combinations are demonstrated. Marked (85-fold) stimulation of tCT secretion occurs in response to combinations of synthetic secretin (5 x 10-5M) with pentagastrin (10-6M) or the carboxyl-terminal octapeptide of pancreozymin (10-6M). These findings have significance with regard to the potentiation of hormone action, and are preliminary evidence for the presence of separate receptors for various enteric peptide secretagogues on C-cells.

UR - http://www.scopus.com/inward/record.url?scp=0017682234&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017682234&partnerID=8YFLogxK

M3 - Article

C2 - 858283

AN - SCOPUS:0017682234

VL - 100

SP - 1679

EP - 1683

JO - Endocrinology

JF - Endocrinology

SN - 0013-7227

IS - 6

ER -