Calciphylaxis with peau d'orange induration and absence of classical features of purpura, livedo reticularis and ulcers

Walter K. Nahm, Evangelos Badiavas, Dany J. Touma, Caroline S. Wilkel, Vincent Falanga

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Calciphylaxis is an ill-defined syndrome that is commonly associated with chronic renal failure. Its heterogeneous clinical features include painful livedo reticularis-like purpuric patches and plaques, vesicles, irregularly shaped ulcers, and black eschars. Despite demonstration of extensive vascular arteriolar calcification in this syndrome, its exact pathogenesis remains unknown. Here, we report a case of calciphylaxis presenting with indurated plaques without the usual clinical picture of livedo reticulate purpura, ulcers or necrotic eschars. This case provides an opportunity to review the clinical spectrum of calciphylaxis and to discuss the therapeutic approaches and pathogenesis of this syndrome from deep intra-wall vascular calcification to the resulting infarctions of adjacent tissues.

Original languageEnglish (US)
Pages (from-to)209-213
Number of pages5
JournalJournal of Dermatology
Volume29
Issue number4
DOIs
StatePublished - Jan 1 2002
Externally publishedYes

Keywords

  • Calciphylaxis
  • Calcium
  • Infarction
  • Peau d'orange
  • Vascular calcification

ASJC Scopus subject areas

  • Dermatology

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