Caffeinol confers cortical but not subcortical neuroprotection after transient focal cerebral ischemia in rats

Ludmila Belayev, Larissa Khoutorova, Yongbo Zhang, Andrey Belayev, Weizhao Zhao, Raul Busto, Myron Ginsberg

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

The combination of low-dose ethanol and caffeine (caffeinol) protects cortical areas of the brain from damage produced by distal focal ischemia in rats. There are no data, however, as to whether caffeinol influences injury in subcortical brain regions. Rats were anesthetized with halothane and subjected to 2 h of MCAo by poly-L-lysine-coated intraluminal suture. Caffeinol [a combination of ethanol, 0.33 g/kg, and caffeine, 10 mg/kg (n=5)] or vehicle (0.9% NaCl; n=7) was administered by i.v. infusion over a 2.5-h period beginning 15 min after reperfusion. Neurological status was evaluated daily, and histopathology was quantified at 3 days. Caffeinol therapy significantly improved the neurological score, reduced the total infarct volume (by 52%) and cortical infarct areas at multiple coronal levels, but subcortical infarction and brain swelling were not affected.

Original languageEnglish
Pages (from-to)278-283
Number of pages6
JournalBrain Research
Volume1008
Issue number2
DOIs
StatePublished - May 22 2004

Fingerprint

Transient Ischemic Attack
Caffeine
Ethanol
Brain Edema
Cerebral Infarction
Brain
Halothane
Sutures
Lysine
Reperfusion
Ischemia
caffeinol
Neuroprotection
Wounds and Injuries
Therapeutics

Keywords

  • Animal model
  • Disorders of the nervous system
  • Focal cerebral ischemia
  • Ischemia
  • Neuroprotection
  • Stroke

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Caffeinol confers cortical but not subcortical neuroprotection after transient focal cerebral ischemia in rats. / Belayev, Ludmila; Khoutorova, Larissa; Zhang, Yongbo; Belayev, Andrey; Zhao, Weizhao; Busto, Raul; Ginsberg, Myron.

In: Brain Research, Vol. 1008, No. 2, 22.05.2004, p. 278-283.

Research output: Contribution to journalArticle

Belayev, Ludmila ; Khoutorova, Larissa ; Zhang, Yongbo ; Belayev, Andrey ; Zhao, Weizhao ; Busto, Raul ; Ginsberg, Myron. / Caffeinol confers cortical but not subcortical neuroprotection after transient focal cerebral ischemia in rats. In: Brain Research. 2004 ; Vol. 1008, No. 2. pp. 278-283.
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