Cadmium-induced postaxial forelimb ectrodactyly: Association with altered sonic hedgehog signaling

William J. Scott, Claire M. Schreiner, John A. Goetz, David Robbins, Sheila M. Bell

Research output: Contribution to journalArticlepeer-review

39 Scopus citations


Administration of CdSO4 to C57BL/6 mice at day 9.5 of gestation induces a high incidence of postaxial forelimb ectrodactyly in the offspring. We propose that Cd2+ exposure impairs the process of anterior/posterior formation in the limb bud, a process that is directed by Sonic hedgehog (Shh) signaling. We show that exposure of the mouse embryo to Cd2+ disrupts Shh signaling as measured by polarizing activity of mouse limb bud ZPA grafted to a host chick wing, and activity of a Gli:luciferase reporter exposed to limb bud lysates. Yet the expression of Shh and its translation are not affected by Cd2+ exposure. We propose that teratogen exposure affects the processing of Shh in the cells in which it is made.

Original languageEnglish (US)
Pages (from-to)479-485
Number of pages7
JournalReproductive Toxicology
Issue number4
StatePublished - Jan 1 2005
Externally publishedYes


  • Cadmium
  • Fgf8
  • Gli/luciferase reporter
  • Gli3
  • Patched
  • Polarizing activity
  • Postaxial forelimb ectrodactyly
  • Sonic hedgehog

ASJC Scopus subject areas

  • Toxicology


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