c-ret and signal transduction

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

DURING THE PAST few years, much effort has been made to understand the function of the proto-oncogene c-ret, a putative receptor tyrosine kinase. Mice homozygous for a null c-ret allele showed severe kidney abnormalities and lacked enteric neurons, indicating that c-ret is involved in the development and differentiation of the kidney and enteric nervous system. The c-ret proto-oncogene can be activated by either DNA rearrangement, in which its tyrosine kinase domain is fused to other genes, or by point mutations in specific domains. Point mutations in c-ret have been linked to several inherited human cancer syndromes, including multiple endocrine neoplasia type 2A and 2B and familial medullary thyroid carcinoma. These recombinations and point mutations may interfere with the function of normal c-ret in a signaling pathway, which subsequently results in cellular transformation.

Original languageEnglish
Pages (from-to)119-124
Number of pages6
JournalCancer Bulletin
Volume47
Issue number2
StatePublished - Jan 1 1995
Externally publishedYes

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Point Mutation
Signal Transduction
Proto-Oncogenes
Multiple Endocrine Neoplasia Type 2b
Multiple Endocrine Neoplasia Type 2a
Enteric Nervous System
Kidney
Gene Rearrangement
Receptor Protein-Tyrosine Kinases
Protein-Tyrosine Kinases
Genetic Recombination
Alleles
Neurons
Genes
Neoplasms

ASJC Scopus subject areas

  • Cancer Research

Cite this

c-ret and signal transduction. / Wikramanayake, Tongyu.

In: Cancer Bulletin, Vol. 47, No. 2, 01.01.1995, p. 119-124.

Research output: Contribution to journalArticle

Wikramanayake, T 1995, 'c-ret and signal transduction', Cancer Bulletin, vol. 47, no. 2, pp. 119-124.
Wikramanayake, Tongyu. / c-ret and signal transduction. In: Cancer Bulletin. 1995 ; Vol. 47, No. 2. pp. 119-124.
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