Abstract
DURING THE PAST few years, much effort has been made to understand the function of the proto-oncogene c-ret, a putative receptor tyrosine kinase. Mice homozygous for a null c-ret allele showed severe kidney abnormalities and lacked enteric neurons, indicating that c-ret is involved in the development and differentiation of the kidney and enteric nervous system. The c-ret proto-oncogene can be activated by either DNA rearrangement, in which its tyrosine kinase domain is fused to other genes, or by point mutations in specific domains. Point mutations in c-ret have been linked to several inherited human cancer syndromes, including multiple endocrine neoplasia type 2A and 2B and familial medullary thyroid carcinoma. These recombinations and point mutations may interfere with the function of normal c-ret in a signaling pathway, which subsequently results in cellular transformation.
| Original language | English |
|---|---|
| Pages (from-to) | 119-124 |
| Number of pages | 6 |
| Journal | Cancer Bulletin |
| Volume | 47 |
| Issue number | 2 |
| State | Published - Jan 1 1995 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Cancer Research
Cite this
c-ret and signal transduction. / Wikramanayake, Tongyu.
In: Cancer Bulletin, Vol. 47, No. 2, 01.01.1995, p. 119-124.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - c-ret and signal transduction
AU - Wikramanayake, Tongyu
PY - 1995/1/1
Y1 - 1995/1/1
N2 - DURING THE PAST few years, much effort has been made to understand the function of the proto-oncogene c-ret, a putative receptor tyrosine kinase. Mice homozygous for a null c-ret allele showed severe kidney abnormalities and lacked enteric neurons, indicating that c-ret is involved in the development and differentiation of the kidney and enteric nervous system. The c-ret proto-oncogene can be activated by either DNA rearrangement, in which its tyrosine kinase domain is fused to other genes, or by point mutations in specific domains. Point mutations in c-ret have been linked to several inherited human cancer syndromes, including multiple endocrine neoplasia type 2A and 2B and familial medullary thyroid carcinoma. These recombinations and point mutations may interfere with the function of normal c-ret in a signaling pathway, which subsequently results in cellular transformation.
AB - DURING THE PAST few years, much effort has been made to understand the function of the proto-oncogene c-ret, a putative receptor tyrosine kinase. Mice homozygous for a null c-ret allele showed severe kidney abnormalities and lacked enteric neurons, indicating that c-ret is involved in the development and differentiation of the kidney and enteric nervous system. The c-ret proto-oncogene can be activated by either DNA rearrangement, in which its tyrosine kinase domain is fused to other genes, or by point mutations in specific domains. Point mutations in c-ret have been linked to several inherited human cancer syndromes, including multiple endocrine neoplasia type 2A and 2B and familial medullary thyroid carcinoma. These recombinations and point mutations may interfere with the function of normal c-ret in a signaling pathway, which subsequently results in cellular transformation.
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UR - http://www.scopus.com/inward/citedby.url?scp=0029039168&partnerID=8YFLogxK
M3 - Article
VL - 47
SP - 119
EP - 124
JO - Cancer Bulletin
JF - Cancer Bulletin
SN - 0008-5448
IS - 2
ER -