C-reactive protein is associated with disability independently of vascular events: The Northern Manhattan Study

Mandip S. Dhamoon, Ying Kuen Cheung, Yeseon P. Moon, Clinton B Wright, Joshua Z. Willey, Ralph L Sacco, Mitchell S.V. Elkind

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: high-sensitivity C-reactive protein (CRP) has been associated with cardiovascular events and mortality, but the association of CRP with functional status is not well defined. We hypothesised that serum levels of high-sensitivity CRP are associated with long-term trajectories of functional status independently of vascular risk factors and stroke and myocardial infarction (MI) occurring during follow-up. Design: prospective, population-based. Setting: northern Manhattan Study. Participants: stroke-free participants aged ≥40 years. Measurements: annual assessments of disability with the Barthel index (BI) for a median of 13 years. BI was analysed as a continuous variable (range 0-100). Baseline demographics, risk factors and laboratory studies were collected, including CRP (n = 2,240). Separate generalised estimating equation models estimated standardised associations between CRP and (i) baseline functional status and (ii) change in function over time, adjusting for demographics, vascular risk factors, social variables, cognition, and depression measured at baseline, and stroke and MI occurring during follow-up. Results: mean age was 69 (SD 10) years, 36% were male, 55% Hispanic, 75% hypertensive and 21% diabetic; 337 MIs and 369 first strokes occurred during follow-up. Mean CRP level was 5.24 mg/l (SD 8.86). logCRP was associated with baseline BI (-0.34 BI points per unit logCRP, 95% confidence interval -0.62, -0.06) but not with change over time. Conclusions: in this large population-based study, higher serum CRP levels were associated with higher baseline disability, even when adjusting for baseline covariates and stroke and MI occurring during follow-up. Systemic inflammation may contribute to disability independently of clinical vascular events.

Original languageEnglish (US)
Pages (from-to)77-83
Number of pages7
JournalAge and Ageing
Volume46
Issue number1
DOIs
StatePublished - 2017

Fingerprint

C-Reactive Protein
Blood Vessels
Stroke
Myocardial Infarction
Demography
Hispanic Americans
Cognition
Population
Blood Proteins
Confidence Intervals
Depression
Inflammation
Mortality
Serum

Keywords

  • C-reactive protein
  • Disability
  • Epidemiology
  • Older people

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology

Cite this

Dhamoon, M. S., Cheung, Y. K., Moon, Y. P., Wright, C. B., Willey, J. Z., Sacco, R. L., & Elkind, M. S. V. (2017). C-reactive protein is associated with disability independently of vascular events: The Northern Manhattan Study. Age and Ageing, 46(1), 77-83. https://doi.org/10.1093/ageing/afw179

C-reactive protein is associated with disability independently of vascular events : The Northern Manhattan Study. / Dhamoon, Mandip S.; Cheung, Ying Kuen; Moon, Yeseon P.; Wright, Clinton B; Willey, Joshua Z.; Sacco, Ralph L; Elkind, Mitchell S.V.

In: Age and Ageing, Vol. 46, No. 1, 2017, p. 77-83.

Research output: Contribution to journalArticle

Dhamoon, Mandip S. ; Cheung, Ying Kuen ; Moon, Yeseon P. ; Wright, Clinton B ; Willey, Joshua Z. ; Sacco, Ralph L ; Elkind, Mitchell S.V. / C-reactive protein is associated with disability independently of vascular events : The Northern Manhattan Study. In: Age and Ageing. 2017 ; Vol. 46, No. 1. pp. 77-83.
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abstract = "Background: high-sensitivity C-reactive protein (CRP) has been associated with cardiovascular events and mortality, but the association of CRP with functional status is not well defined. We hypothesised that serum levels of high-sensitivity CRP are associated with long-term trajectories of functional status independently of vascular risk factors and stroke and myocardial infarction (MI) occurring during follow-up. Design: prospective, population-based. Setting: northern Manhattan Study. Participants: stroke-free participants aged ≥40 years. Measurements: annual assessments of disability with the Barthel index (BI) for a median of 13 years. BI was analysed as a continuous variable (range 0-100). Baseline demographics, risk factors and laboratory studies were collected, including CRP (n = 2,240). Separate generalised estimating equation models estimated standardised associations between CRP and (i) baseline functional status and (ii) change in function over time, adjusting for demographics, vascular risk factors, social variables, cognition, and depression measured at baseline, and stroke and MI occurring during follow-up. Results: mean age was 69 (SD 10) years, 36{\%} were male, 55{\%} Hispanic, 75{\%} hypertensive and 21{\%} diabetic; 337 MIs and 369 first strokes occurred during follow-up. Mean CRP level was 5.24 mg/l (SD 8.86). logCRP was associated with baseline BI (-0.34 BI points per unit logCRP, 95{\%} confidence interval -0.62, -0.06) but not with change over time. Conclusions: in this large population-based study, higher serum CRP levels were associated with higher baseline disability, even when adjusting for baseline covariates and stroke and MI occurring during follow-up. Systemic inflammation may contribute to disability independently of clinical vascular events.",
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T1 - C-reactive protein is associated with disability independently of vascular events

T2 - The Northern Manhattan Study

AU - Dhamoon, Mandip S.

AU - Cheung, Ying Kuen

AU - Moon, Yeseon P.

AU - Wright, Clinton B

AU - Willey, Joshua Z.

AU - Sacco, Ralph L

AU - Elkind, Mitchell S.V.

PY - 2017

Y1 - 2017

N2 - Background: high-sensitivity C-reactive protein (CRP) has been associated with cardiovascular events and mortality, but the association of CRP with functional status is not well defined. We hypothesised that serum levels of high-sensitivity CRP are associated with long-term trajectories of functional status independently of vascular risk factors and stroke and myocardial infarction (MI) occurring during follow-up. Design: prospective, population-based. Setting: northern Manhattan Study. Participants: stroke-free participants aged ≥40 years. Measurements: annual assessments of disability with the Barthel index (BI) for a median of 13 years. BI was analysed as a continuous variable (range 0-100). Baseline demographics, risk factors and laboratory studies were collected, including CRP (n = 2,240). Separate generalised estimating equation models estimated standardised associations between CRP and (i) baseline functional status and (ii) change in function over time, adjusting for demographics, vascular risk factors, social variables, cognition, and depression measured at baseline, and stroke and MI occurring during follow-up. Results: mean age was 69 (SD 10) years, 36% were male, 55% Hispanic, 75% hypertensive and 21% diabetic; 337 MIs and 369 first strokes occurred during follow-up. Mean CRP level was 5.24 mg/l (SD 8.86). logCRP was associated with baseline BI (-0.34 BI points per unit logCRP, 95% confidence interval -0.62, -0.06) but not with change over time. Conclusions: in this large population-based study, higher serum CRP levels were associated with higher baseline disability, even when adjusting for baseline covariates and stroke and MI occurring during follow-up. Systemic inflammation may contribute to disability independently of clinical vascular events.

AB - Background: high-sensitivity C-reactive protein (CRP) has been associated with cardiovascular events and mortality, but the association of CRP with functional status is not well defined. We hypothesised that serum levels of high-sensitivity CRP are associated with long-term trajectories of functional status independently of vascular risk factors and stroke and myocardial infarction (MI) occurring during follow-up. Design: prospective, population-based. Setting: northern Manhattan Study. Participants: stroke-free participants aged ≥40 years. Measurements: annual assessments of disability with the Barthel index (BI) for a median of 13 years. BI was analysed as a continuous variable (range 0-100). Baseline demographics, risk factors and laboratory studies were collected, including CRP (n = 2,240). Separate generalised estimating equation models estimated standardised associations between CRP and (i) baseline functional status and (ii) change in function over time, adjusting for demographics, vascular risk factors, social variables, cognition, and depression measured at baseline, and stroke and MI occurring during follow-up. Results: mean age was 69 (SD 10) years, 36% were male, 55% Hispanic, 75% hypertensive and 21% diabetic; 337 MIs and 369 first strokes occurred during follow-up. Mean CRP level was 5.24 mg/l (SD 8.86). logCRP was associated with baseline BI (-0.34 BI points per unit logCRP, 95% confidence interval -0.62, -0.06) but not with change over time. Conclusions: in this large population-based study, higher serum CRP levels were associated with higher baseline disability, even when adjusting for baseline covariates and stroke and MI occurring during follow-up. Systemic inflammation may contribute to disability independently of clinical vascular events.

KW - C-reactive protein

KW - Disability

KW - Epidemiology

KW - Older people

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