Abstract
Blood lipids and high-sensitivity C-reactive protein (hsCRP) are used to assess cardiovascular disease (CVD) risk. We evaluated in a cross-sectional design the relationship of hsCRP to markers of liver function (aspartate and alanine transaminases [AST and ALT, respectively]), CVD risk factors and HIV-disease progression markers in 226 HIV-1 sero-positive drug users. hsCRP showed a significant inverse relationship with ALT and high-density lipoprotein, independent of age, gender, viral load, CD4 cellcount and antiretroviral (ARV) use, and was not significantly associated with HIV-disease progression markers. Serum markers of liver damage, AST and ALT, were associated with lower hsCRP, total cholesterol, low-density lipoproteins and triglycerides. Elevated liver enzymes (≥40 IU/L) were predictive of hsCRP levels that are considered a low risk for CVD. In conclusion, hsCRP may not be a reliable marker of CVD risk in populations with HIV at-risk for elevated liver enzymes due to high hepatitis B virus/hepatitis C virus prevalence and ARV use.
| Original language | English |
|---|---|
| Pages (from-to) | 410-413 |
| Number of pages | 4 |
| Journal | International Journal of STD and AIDS |
| Volume | 19 |
| Issue number | 6 |
| DOIs | |
| State | Published - Jun 1 2008 |
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Keywords
- ALT
- AST
- C-reactive protein
- CVD risk
- HIV-1
- Liver damage
ASJC Scopus subject areas
- Dermatology
- Public Health, Environmental and Occupational Health
- Microbiology (medical)
- Immunology
Cite this
C-reactive protein : A poor marker of cardiovascular disease risk in HIV+ populations with a high prevalence of elevated serum transaminases. / Baum, Marianna K.; Rafie, C.; Sales, S.; Lai, S.; Duan, R.; Jayaweera, Dushyantha T; Page, John; Campa, A.
In: International Journal of STD and AIDS, Vol. 19, No. 6, 01.06.2008, p. 410-413.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - C-reactive protein
T2 - A poor marker of cardiovascular disease risk in HIV+ populations with a high prevalence of elevated serum transaminases
AU - Baum, Marianna K.
AU - Rafie, C.
AU - Sales, S.
AU - Lai, S.
AU - Duan, R.
AU - Jayaweera, Dushyantha T
AU - Page, John
AU - Campa, A.
PY - 2008/6/1
Y1 - 2008/6/1
N2 - Blood lipids and high-sensitivity C-reactive protein (hsCRP) are used to assess cardiovascular disease (CVD) risk. We evaluated in a cross-sectional design the relationship of hsCRP to markers of liver function (aspartate and alanine transaminases [AST and ALT, respectively]), CVD risk factors and HIV-disease progression markers in 226 HIV-1 sero-positive drug users. hsCRP showed a significant inverse relationship with ALT and high-density lipoprotein, independent of age, gender, viral load, CD4 cellcount and antiretroviral (ARV) use, and was not significantly associated with HIV-disease progression markers. Serum markers of liver damage, AST and ALT, were associated with lower hsCRP, total cholesterol, low-density lipoproteins and triglycerides. Elevated liver enzymes (≥40 IU/L) were predictive of hsCRP levels that are considered a low risk for CVD. In conclusion, hsCRP may not be a reliable marker of CVD risk in populations with HIV at-risk for elevated liver enzymes due to high hepatitis B virus/hepatitis C virus prevalence and ARV use.
AB - Blood lipids and high-sensitivity C-reactive protein (hsCRP) are used to assess cardiovascular disease (CVD) risk. We evaluated in a cross-sectional design the relationship of hsCRP to markers of liver function (aspartate and alanine transaminases [AST and ALT, respectively]), CVD risk factors and HIV-disease progression markers in 226 HIV-1 sero-positive drug users. hsCRP showed a significant inverse relationship with ALT and high-density lipoprotein, independent of age, gender, viral load, CD4 cellcount and antiretroviral (ARV) use, and was not significantly associated with HIV-disease progression markers. Serum markers of liver damage, AST and ALT, were associated with lower hsCRP, total cholesterol, low-density lipoproteins and triglycerides. Elevated liver enzymes (≥40 IU/L) were predictive of hsCRP levels that are considered a low risk for CVD. In conclusion, hsCRP may not be a reliable marker of CVD risk in populations with HIV at-risk for elevated liver enzymes due to high hepatitis B virus/hepatitis C virus prevalence and ARV use.
KW - ALT
KW - AST
KW - C-reactive protein
KW - CVD risk
KW - HIV-1
KW - Liver damage
UR - http://www.scopus.com/inward/record.url?scp=47949094134&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=47949094134&partnerID=8YFLogxK
U2 - 10.1258/ijsa.2007.007207
DO - 10.1258/ijsa.2007.007207
M3 - Article
C2 - 18595880
AN - SCOPUS:47949094134
VL - 19
SP - 410
EP - 413
JO - International Journal of STD and AIDS
JF - International Journal of STD and AIDS
SN - 0956-4624
IS - 6
ER -