c-fos elimination compensates for disabled-2 requirement in mouse extraembryonic endoderm development

Dong Hua Yang, Elizabeth R. Smith, Kathy Qi Cai, Xiang Xi Michael Xu

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Disabled-2 (Dab2) is expressed in primitive endoderm cells as they are differentiating from the inner cell mass and dab2 deficiency in mice results in lethality at E5.5-E6.5 due to the disorganization of the endoderm layers. Here we show that Dab2 suppresses c-Fos expression in endoderm cells. A morphological normal primitive endoderm layer was observed in putative E5.5 dab2 (-/-):c-fos (-/-) embryos, indicating that the primitive endoderm defect due to the loss of Dab2 is rescued by deletion of the c-fos gene. The lethality of the double knockout embryos was delayed until E9.5-E10.5 and the defective embryos failed to undergo organogenesis. We conclude that Dab2 plays a role in epithelial organization by suppression of c-Fos expression and suggest that unsuppressed c-Fos can lead to disruption of primitive endoderm epithelial organization, yet an additional dab2 function is required for later organogenesis.

Original languageEnglish (US)
Pages (from-to)514-523
Number of pages10
JournalDevelopmental Dynamics
Issue number3
StatePublished - Mar 2009


  • c-Fos
  • Cell positioning/organization
  • Cell surface positioning
  • Disabled-2 (Dab2)
  • Epithelial polarity
  • MAPK
  • Mouse embryos
  • Primitive endoderm

ASJC Scopus subject areas

  • Developmental Biology


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